Lozada-Mellado Mariel, Llorente Luis, Hinojosa-Azaola Andrea, García-Morales José M, Ogata-Medel Midori, Alcocer-Varela Jorge, Pineda-Juárez Juan A, Castillo-Martínez Lilia
Clinical Nutrition Service, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
Front Nutr. 2022 Apr 25;9:834824. doi: 10.3389/fnut.2022.834824. eCollection 2022.
Rheumatoid arthritis (RA) is a disease characterized by a chronic inflammatory state. High pro-inflammatory cytokine levels are associated with disease activity. Exercise and the Mediterranean diet (MD) exert anti-inflammatory effects; however, their impacts on inflammation in RA patients remains unknown. This study aimed to compare the effects of six-months of dynamic exercise program (DEP) vs. MD on pro- and anti-inflammatory cytokine serum concentrations.
Secondary analysis of a randomized clinical trial in which 90 women with RA were randomly assigned to the DEP ( = 30), MD ( = 30), or control group ( = 30). All patients received pharmacological treatment. Serum concentrations of pro-inflammatory (TNF-α, TNF-β, IL-1β, IL-6 pg/mL) and anti-inflammatory (IL-10, IL-Ra pg/mL) cytokines were measured at baseline and after 6 months using the Luminex technique.
After 6 months of follow-up, we found an improvement of the median percentages changes concentrations of TNF-α (DEP, -12.3; MD, -13.3; control, 73.2; = 0.01), TNF-β (DEP, -67.4; MD, -54.9; control, 0; = 0.04), and IL-6 (DEP, -19.9; MD, -37.7; control, 45.5; = 0.04) in the DEP and MED groups in comparison with control group. IL-1Ra concentrations increased only in the MD group (13.8) compared to levels in the control group (-31.7), = 0.04. There were no statistically significant differences between DEP and MD groups. Only = 27 participants in the DEP group, = 26 in the MD group, and = 21 in the control group completed the follow-up.
The DEP and the MD have potential effects in the concentrations of pro-inflammatory cytokines compared with those in a control group. Only the MD elevated the concentration of IL-Ra.
[ClinicalTrials.gov], identifier [NCT02900898].
类风湿性关节炎（RA）是一种以慢性炎症状态为特征的疾病。促炎细胞因子水平升高与疾病活动相关。运动和地中海饮食（MD）具有抗炎作用；然而，它们对RA患者炎症的影响尚不清楚。本研究旨在比较为期六个月的动态运动计划（DEP）与MD对促炎和抗炎细胞因子血清浓度的影响。
对一项随机临床试验进行二次分析，将90名RA女性随机分为DEP组（n = 30）、MD组（n = 30）或对照组（n = 30）。所有患者均接受药物治疗。使用Luminex技术在基线和6个月后测量促炎（TNF-α、TNF-β、IL-1β、IL-6 pg/mL）和抗炎（IL-10、IL-Ra pg/mL）细胞因子的血清浓度。
随访6个月后，我们发现与对照组相比，DEP组和MD组中TNF-α（DEP组，-12.3；MD组，-13.3；对照组，73.2；P = 0.01）、TNF-β（DEP组，-67.4；MD组，-54.9；对照组，0；P = 0.04）和IL-6（DEP组，-19.9；MD组，-37.7；对照组，45.5；P = 0.04）的中位数百分比变化浓度有所改善。与对照组水平（-31.7）相比，仅MD组的IL-1Ra浓度增加（13.8），P = 0.04。DEP组和MD组之间无统计学显著差异。DEP组仅27名参与者、MD组26名参与者和对照组21名参与者完成了随访。
与对照组相比，DEP和MD对促炎细胞因子浓度有潜在影响。只有MD提高了IL-Ra的浓度。
[ClinicalTrials.gov]标识符[NCT02900898]
