有机催化的硫代迈克尔/羟醛串联反应：构建带有季碳立体中心的官能化2,5-二氢噻吩
Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter.
作者信息
Zhu Xiao-Yu, Lv Mei-Heng, Zhao Ya-Nan, Lan Li-Yan, Li Wen-Ze, Xiao Lin-Jiu
机构信息
College of Applied Chemistry, Shenyang University of Chemical Technology Shenyang 110142 China
出版信息
RSC Adv. 2018 Oct 3;8(59):34000-34003. doi: 10.1039/c8ra04325f. eCollection 2018 Sep 28.
Abstract
A practical sulfa-Michael/aldol cascade reaction of 1,4-dithiane-2,5-diol and α-aryl-β-nitroacrylates has been developed, which allows efficient access to functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter in moderate to good yields with high enantioselectivities.
摘要
已开发出一种1,4 - 二硫杂环己烷 - 2,5 - 二醇与α - 芳基 - β - 硝基丙烯酸酯的实用硫醚 - 迈克尔/羟醛串联反应，该反应能够以中等到良好的产率和高对映选择性高效合成带有季碳立体中心的官能化2,5 - 二氢噻吩。
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