Kim Soo Jeong, Chang Hyungseok, Youn Inyoung, Joo Kwan Joong, Ryu Seungho, Kim Young Hwan
Department of Nuclear Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Diagn Interv Radiol. 2022 Mar;28(2):179-184. doi: 10.5152/dir.2022.20677.
PURPOSE Inflammation is known to induce prostatic growth and lower urinary tract symptoms (LUTS) progression in patients with benign prostatic hyperplasia (BPH), but clinical indicators for intraprostatic inflammation other than biopsy have not yet been established. While 2-deoxy- 2-[18F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) is a useful tool for investigating inflammatory conditions, prostatic FDG uptake in patients with BPH has not been elucidated. Therefore, we evaluated the association between prostatic FDG uptake and LUTS. METHODS A total of 391 men in their 50s who underwent FDG PET/CT during health examinations were included. Mean and maximal prostatic standard uptake values (SUVs) on FDG PET/CT were measured. Prostatic volume, focal FDG uptake, and calcification were also evaluated. The International Prostate Symptom Score (IPSS) for LUTS was collected at baseline and follow- ups. The correlation between IPSS and other variables was analyzed. RESULTS The mean age of the study participants was 51.7 years, and the mean follow-up interval was 39.7 months. The average of the mean and maximal SUV for prostatic FDG uptake was 1.8 and 2.6, respectively. The prostate volume was 18.5 cm3. The mean IPSS was 4.82 at baseline and 5.46 at follow-ups. Neither the mean SUV nor the maximal SUV of prostatic FDG uptake was correlated with IPSS at baseline or follow-ups. Conversely, prostate volume was associated with baseline IPSS and follow-up IPSS. CONCLUSION Prostatic FDG uptake did not show a significant association with IPSS on FDG PET/CT as well as at follow-ups. FDG uptake may not reflect prostatic growth in nonmalignant cases.
目的 已知炎症会促使良性前列腺增生（BPH）患者的前列腺生长并导致下尿路症状（LUTS）进展，但除活检外，尚未确立前列腺内炎症的临床指标。虽然2-脱氧-2-[18F]氟-D-葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）是用于研究炎症状况的有用工具，但BPH患者前列腺FDG摄取情况尚未阐明。因此，我们评估了前列腺FDG摄取与LUTS之间的关联。方法 纳入了391名50多岁在健康体检期间接受FDG PET/CT检查的男性。测量了FDG PET/CT上前列腺的平均和最大标准摄取值（SUV）。还评估了前列腺体积、局灶性FDG摄取和钙化情况。在基线和随访时收集LUTS的国际前列腺症状评分（IPSS）。分析IPSS与其他变量之间的相关性。结果 研究参与者的平均年龄为51.7岁，平均随访间隔为39.7个月。前列腺FDG摄取的平均SUV和最大SUV平均值分别为1.8和2.6。前列腺体积为18.5 cm³。基线时平均IPSS为4.82，随访时为5.46。前列腺FDG摄取的平均SUV和最大SUV在基线或随访时均与IPSS无相关性。相反，前列腺体积与基线IPSS和随访IPSS相关。结论 在FDG PET/CT以及随访时，前列腺FDG摄取与IPSS未显示出显著关联。在非恶性病例中，FDG摄取可能无法反映前列腺生长情况。
