临床良性前列腺增生症的流行病学
Epidemiology of clinical benign prostatic hyperplasia.
作者信息
Lim Kok Bin
机构信息
Raffles Urology Centre, Raffles Hospital, Singapore.
出版信息
Asian J Urol. 2017 Jul;4(3):148-151. doi: 10.1016/j.ajur.2017.06.004. Epub 2017 Jun 9.
Abstract
Clinical benign prostatic hyperplasia (BPH) is one of the most common diseases in ageing men and the most common cause of lower urinary tract symptoms (LUTS). The prevalence of BPH increases after the age of 40 years, with a prevalence of 8%-60% at age 90 years. Some data have suggested that there is decreased risk among the Asians compared to the western white population. Genetics, diet and life style may play a role here. Recent reports suggest the strong relationship of clinical BPH with metabolic syndrome and erectile dysfunction, as well as the possible role of inflammation as a cause of the prostatic hyperplasia. Lifestyle changes including exercise and diet are important strategies in controlling this common ailment.
摘要
临床良性前列腺增生（BPH）是老年男性中最常见的疾病之一，也是下尿路症状（LUTS）的最常见原因。BPH的患病率在40岁以后上升，90岁时患病率为8%-60%。一些数据表明，与西方白种人群相比，亚洲人的患病风险较低。遗传、饮食和生活方式可能在此起作用。最近的报告表明临床BPH与代谢综合征和勃起功能障碍之间存在密切关系，以及炎症作为前列腺增生病因的可能作用。包括运动和饮食在内的生活方式改变是控制这种常见疾病的重要策略。
相似文献
1
Epidemiology of clinical benign prostatic hyperplasia.临床良性前列腺增生症的流行病学
Asian J Urol. 2017 Jul;4(3):148-151. doi: 10.1016/j.ajur.2017.06.004. Epub 2017 Jun 9.
2
Epidemiology and risk factors of lower urinary tract symptoms/benign prostatic hyperplasia and erectile dysfunction.下尿路症状/良性前列腺增生与勃起功能障碍的流行病学及危险因素
Aging Male. 2019 Mar;22(1):12-19. doi: 10.1080/13685538.2018.1434772. Epub 2018 Feb 2.
3
Critical analysis of the relationship between sexual dysfunctions and lower urinary tract symptoms due to benign prostatic hyperplasia.良性前列腺增生所致下尿路症状与性功能障碍关系的批判性分析。
Eur Urol. 2011 Oct;60(4):809-25. doi: 10.1016/j.eururo.2011.06.037. Epub 2011 Jun 29.
4
Burden of male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) - focus on the UK.提示良性前列腺增生（BPH）的男性下尿路症状（LUTS）负担——聚焦英国
BJU Int. 2015 Apr;115(4):508-19. doi: 10.1111/bju.12745. Epub 2014 Oct 16.
5
Treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: sexual function.疑似良性前列腺增生的下尿路症状的治疗：性功能
BJU Int. 2005 Jun;95 Suppl 4:12-8. doi: 10.1111/j.1464-410X.2005.05486.x.
6
A new experimental rat model of erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: the testosterone-supplemented spontaneously hypertensive rat.一种新型与良性前列腺增生相关的勃起功能障碍和下尿路症状的实验性大鼠模型：补充睾酮的自发性高血压大鼠。
BJU Int. 2012 Nov;110(9):1352-8. doi: 10.1111/j.1464-410X.2012.11085.x. Epub 2012 Mar 27.
7
Current benign prostatic hyperplasia treatment: impact on sexual function and management of related sexual adverse events.当前良性前列腺增生症的治疗：对性功能的影响及相关性功能不良事件的管理。
Int J Clin Pract. 2011 Sep;65(9):1005-13. doi: 10.1111/j.1742-1241.2011.02731.x. Epub 2011 Jul 1.
8
Effects of tadalafil on lower urinary tract symptoms secondary to benign prostatic hyperplasia and on erectile dysfunction in sexually active men with both conditions: analyses of pooled data from four randomized, placebo-controlled tadalafil clinical studies.他达拉非对良性前列腺增生继发的下尿路症状及对同时患有这两种病症的性活跃男性勃起功能障碍的影响：来自四项随机、安慰剂对照他达拉非临床研究的汇总数据分析
J Sex Med. 2013 Aug;10(8):2044-52. doi: 10.1111/jsm.12212. Epub 2013 Jun 19.
9
Tadalafil once daily in the treatment of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) in men without erectile dysfunction.他达拉非每日一次治疗男性下尿路症状（LUTS）合并良性前列腺增生（BPH）而无勃起功能障碍。
BJU Int. 2013 Nov;112(7):990-7. doi: 10.1111/bju.12251. Epub 2013 Aug 13.
10
Erectile Dysfunction and Lower Urinary Tract Symptoms.勃起功能障碍与下尿路症状。
Eur Urol Focus. 2017 Oct;3(4-5):352-363. doi: 10.1016/j.euf.2017.11.004. Epub 2017 Nov 27.
引用本文的文献
1
Hidden findings: How often does Holmium laser enucleation of the prostate (HoLEP) uncover prostate cancer?隐匿性发现：钬激光前列腺剜除术（HoLEP）发现前列腺癌的频率有多高？
Int Urol Nephrol. 2025 Aug 31. doi: 10.1007/s11255-025-04769-8.
2
The Interrelationship Between Andropause Symptoms, Testosterone Levels, and Lower Urinary Tract Symptoms in Men With Benign Prostatic Hyperplasia (BPH): A Cross-Sectional Study.良性前列腺增生（BPH）男性的雄激素缺乏症状、睾酮水平与下尿路症状之间的相互关系：一项横断面研究
Cureus. 2025 Jul 26;17(7):e88797. doi: 10.7759/cureus.88797. eCollection 2025 Jul.
3
Unveiling therapeutic targets and preventive components for kidney insufficiency and blood stasis-type BPH: bridging metabolomics, network pharmacology and reverse screening.揭示肾功能不全和血瘀型良性前列腺增生的治疗靶点及预防成分：连接代谢组学、网络药理学与反向筛选
Front Pharmacol. 2025 Jun 19;16:1584766. doi: 10.3389/fphar.2025.1584766. eCollection 2025.
4
The relationship between the triglyceride glucose-waist height ratio and benign prostatic hyperplasia in middle-aged and elderly adults: a nationwide cohort study.中老年人群中甘油三酯葡萄糖-腰围身高比与良性前列腺增生的关系：一项全国性队列研究
BMC Urol. 2025 Jul 3;25(1):153. doi: 10.1186/s12894-025-01844-1.
5
Hydroxychloroquine modulates the progression of experimentally induced benign prostatic hyperplasia in rats via targeting EGFR/ERK/STAT3 and AR/FOXO1/TRAIL pathways: computational and in vivo studies.羟氯喹啉通过靶向表皮生长因子受体/细胞外信号调节激酶/信号转导与转录激活因子3以及雄激素受体/叉头框蛋白O1/肿瘤坏死因子相关凋亡诱导配体通路调控大鼠实验性诱导的良性前列腺增生的进展：计算机模拟和体内研究
Sci Rep. 2025 Jun 20;15(1):20118. doi: 10.1038/s41598-025-04267-y.
6
Minimally invasive surgical techniques (MISTs) for benign prostatic hyperplasia: results from a Delphi consensus project to shed light on controversial topics.良性前列腺增生的微创外科技术：德尔菲共识项目揭示争议性话题的结果
World J Urol. 2025 Jun 8;43(1):363. doi: 10.1007/s00345-025-05727-w.
7
Hydroxycitric acid inhibits ferroptosis and ameliorates benign prostatic hyperplasia by upregulating the Nrf2/GPX4 pathway.羟基柠檬酸通过上调Nrf2/GPX4通路抑制铁死亡并改善良性前列腺增生。
World J Urol. 2025 May 20;43(1):318. doi: 10.1007/s00345-025-05637-x.
8
scPRINT: pre-training on 50 million cells allows robust gene network predictions.scPRINT：在5000万个细胞上进行预训练可实现强大的基因网络预测。
Nat Commun. 2025 Apr 16;16(1):3607. doi: 10.1038/s41467-025-58699-1.
9
Causal association between non-steroidal anti-inflammatory drugs use and the risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study.非甾体抗炎药使用与良性前列腺增生风险之间的因果关联：一项单变量和多变量孟德尔随机化研究
BMC Med Genomics. 2025 Mar 31;18(1):60. doi: 10.1186/s12920-025-02128-1.
10
The Kilogland: Giant prostatic hyperplasia with incidental prostate adenocarcinoma.基洛格兰德：伴有偶发性前列腺腺癌的巨大前列腺增生。
Urol Case Rep. 2025 Mar 7;60:102994. doi: 10.1016/j.eucr.2025.102994. eCollection 2025 May.
本文引用的文献
1
Indications for and use of nonsteroidal antiinflammatory drugs and the risk of incident, symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial.非甾体抗炎药的适应证和用途与新发有症状良性前列腺增生症的风险：来自前列腺癌预防试验的结果。
Am J Epidemiol. 2012 Jul 15;176(2):156-63. doi: 10.1093/aje/kwr524. Epub 2012 Jun 28.
2
Association between physical activity, lower urinary tract symptoms (LUTS) and prostate volume.体力活动与下尿路症状（LUTS）和前列腺体积的关系。
BJU Int. 2013 Jan;111(1):122-8. doi: 10.1111/j.1464-410X.2012.11287.x. Epub 2012 Jun 22.
3
Is high-sensitivity C-reactive protein associated with lower urinary tract symptoms in aging men? Results from the hallym aging study.高敏C反应蛋白与老年男性下尿路症状有关吗？来自翰林衰老研究的结果。
Korean J Urol. 2012 May;53(5):335-41. doi: 10.4111/kju.2012.53.5.335. Epub 2012 May 18.
4
Non-steroidal anti-inflammatory drug use and the risk of benign prostatic hyperplasia-related outcomes and nocturia in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.非甾体抗炎药的使用与前列腺、肺、结直肠和卵巢癌筛查试验中良性前列腺增生相关结局和夜尿症的风险。
BJU Int. 2012 Oct;110(7):1050-9. doi: 10.1111/j.1464-410X.2011.10867.x. Epub 2012 Mar 19.
5
Obesity increases and physical activity decreases lower urinary tract symptom risk in older men: the Osteoporotic Fractures in Men study.肥胖增加，体力活动减少与老年男性下尿路症状风险相关：男性骨质疏松性骨折研究。
Eur Urol. 2011 Dec;60(6):1173-80. doi: 10.1016/j.eururo.2011.07.040. Epub 2011 Jul 23.
6
Statin use and decreased risk of benign prostatic enlargement and lower urinary tract symptoms.他汀类药物的使用与良性前列腺增生和下尿路症状风险降低有关。
BJU Int. 2011 Feb;107(3):443-50. doi: 10.1111/j.1464-410X.2010.09598.x. Epub 2010 Aug 26.
7
Biomarkers of systemic inflammation and risk of incident, symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial.系统炎症生物标志物与症状性良性前列腺增生发病风险：前列腺癌预防试验的结果。
Am J Epidemiol. 2010 Mar 1;171(5):571-82. doi: 10.1093/aje/kwp406. Epub 2010 Feb 8.
8
Diabetes and benign prostatic hyperplasia/lower urinary tract symptoms--what do we know?糖尿病与良性前列腺增生/下尿路症状——我们了解多少？
J Urol. 2009 Dec;182(6 Suppl):S32-7. doi: 10.1016/j.juro.2009.07.088.
9
Obesity and benign prostatic hyperplasia: clinical connections, emerging etiological paradigms and future directions.肥胖与良性前列腺增生：临床关联、新兴病因学模式与未来方向。
J Urol. 2009 Dec;182(6 Suppl):S27-31. doi: 10.1016/j.juro.2009.07.086.
10
Alcohol consumption is associated with a decreased risk of benign prostatic hyperplasia.饮酒与良性前列腺增生风险降低有关。
J Urol. 2009 Oct;182(4):1463-8. doi: 10.1016/j.juro.2009.06.038. Epub 2009 Aug 15.
Zotero 插件