Huang Yuming, Tran Hai, Ober Christopher K
ACS Macro Lett. 2021 Jun 15;10(6):755-759. doi: 10.1021/acsmacrolett.1c00187. Epub 2021 May 31.
In this study of nanopatterned helical poly(benzyl-l-glutamate) (PBLG) brushes, rod-type brush arrays were fabricated via an integrated process of high-resolution lithography and surface-initiated vapor deposition polymerization (SI-VDP). "Nanospikes" of polymer brushes with spacings of less than 100 nm were produced. The topology and areal behavior of the resulting patterned rod-like brushes were analyzed and compared with patterned coil-type brushes. A geometric study of these self-assembled "nanospikes" was carried out, and their cross sections were investigated via focused ion beam (FIB) and scanning electron microscopy (SEM). Furthermore, the presence of poly(-isopropylacrylamide) (PNIPAM) brushes in unpatterned regions was shown to inhibit undesired "inter-spike" bridging of the PBLG brushes, resulting in more well-defined nanostructures. It was shown that rod-like polypeptide brushes are capable of self-segregation and become arranged vertically without any external support from their surroundings, to form a rod bundle end-point functional topography that could provide possible pathways for studies of model biological surfaces, directed assembly of nanoparticles, or binary mixed brush surfaces with dual properties.
在这项关于纳米图案化螺旋聚（苄基-L-谷氨酸）（PBLG）刷的研究中，通过高分辨率光刻和表面引发气相沉积聚合（SI-VDP）的集成工艺制备了棒状刷阵列。制备出了间距小于100 nm的聚合物刷“纳米尖峰”。对所得图案化棒状刷的拓扑结构和面积行为进行了分析，并与图案化线圈型刷进行了比较。对这些自组装“纳米尖峰”进行了几何研究，并通过聚焦离子束（FIB）和扫描电子显微镜（SEM）对其横截面进行了研究。此外，结果表明，在未图案化区域存在聚（N-异丙基丙烯酰胺）（PNIPAM）刷可抑制PBLG刷不希望出现的“尖峰间”桥接，从而产生更明确的纳米结构。结果表明，棒状多肽刷能够自我分离，并在没有周围环境任何外部支撑的情况下垂直排列，形成一种棒束端点功能形貌，可为模型生物表面研究、纳米颗粒的定向组装或具有双重性质的二元混合刷表面提供可能的途径。
