Zhao Chaochao, Shi Qin, Li Hu, Cui Xi, Xi Yuan, Cao Yu, Xiang Zhuo, Li Feng, Sun Jinyan, Liu Jiacheng, Li Tongqiang, Wei Wei, Xiong Bin, Li Zhou
Department of Biomedical Engineering, School of Medicine, Foshan University, Foshan 528225, China.
CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.
ACS Nano. 2022 May 24;16(5):8493-8503. doi: 10.1021/acsnano.2c03768. Epub 2022 May 13.
In this study, an intelligent drug delivery system (DDS) based on implanted triboelectric nanogenerator (iTENG) and red blood cell (RBC) is established for hepatocellular carcinoma (HCC) therapy. Apatinib (APA), as an oral antitumor drug, which can inhibit the expression of vascular endothelial growth factor receptor-2 (VEGFR2) is loaded inside RBC, realizing the transform from oral formulation to injection preparation. Multishape designed iTENG adapted for different implant sites and environments can harvest biomechanical energy efficiently. The electric field (EF) generated by the iTENG can increase the release of APA, and the release will decrease quickly when the EF disappears, which shows that the DDS is highly controllable. The controllable DDS demonstrates an exciting killing ability of HCC cells both and with strikingly reduced APA dosage. After implantation, the self-powered DDS has a prominent therapeutic effect of HCC-bearing rabbits, which is expected to be applied in clinical medicine.
在本研究中，基于植入式摩擦纳米发电机（iTENG）和红细胞（RBC）构建了一种用于肝细胞癌（HCC）治疗的智能药物递送系统（DDS）。阿帕替尼（APA）作为一种口服抗肿瘤药物，可抑制血管内皮生长因子受体-2（VEGFR2）的表达，被装载到红细胞内，实现了从口服制剂到注射制剂的转变。多形状设计的iTENG适用于不同的植入部位和环境，能够高效收集生物机械能。iTENG产生的电场（EF）可增加APA的释放，当电场消失时释放会迅速减少，这表明该药物递送系统具有高度可控性。这种可控的药物递送系统在显著降低APA剂量的情况下，对肝癌细胞均表现出令人兴奋的杀伤能力。植入后，自供电的药物递送系统对荷肝癌兔具有显著的治疗效果，有望应用于临床医学。
