月桂对大鼠的降压作用研究。
Study of the Antihypertensive Effect of Laurus nobilis in Rats.
作者信息
Bouadid Ismail, Amssayef Ayoub, Eddouks Mohamed
机构信息
Department of biology, Moulay Ismail University of Meknes, Errachidia, Morocco.
出版信息
Cardiovasc Hematol Agents Med Chem. 2023;21(1):42-54. doi: 10.2174/1871525720666220512154041.
AIMS
The study aimed to study the antihypertensive activity of Laurus nobilis.
BACKGROUND
Laurus nobilis L. is used to treat hypertension in Morocco.
OBJECTIVE
The study was designed to investigate the effect of the aqueous extract leaves of Laurus nobilis (AELN) on blood pressure.
MATERIALS AND METHODS
The antihypertensive and vasorelaxant activities of AELN were pharmacologically investigated in normotensive and L-NAME-induced hypertensive rats. Thereafter, blood pressure was evaluated, and the ex-vivo vasorelaxant activity of this extract was performed.
RESULTS
A considerable decrease in blood pressure parameters were observed in L-NAMEinduced hypertensive rats treated with AELN. The extract induced a vasorelaxant effect on the aorta precontracted with epinephrine or KCl by inhibiting extracellular Ca2+ entry.
CONCLUSION
The study demonstrates that Laurus nobilis aqueous extract exhibits potent antihypertensive and vasorelaxant activities via inhibiting Ca2+ entry.
目的
本研究旨在探究月桂的降压活性。
背景
在摩洛哥，月桂被用于治疗高血压。
目的
本研究旨在调查月桂水提取物（AELN）对血压的影响。
材料与方法
在正常血压和L-NAME诱导的高血压大鼠中，对AELN的降压和血管舒张活性进行了药理学研究。此后，评估血压，并进行该提取物的离体血管舒张活性研究。
结果
在用AELN治疗的L-NAME诱导的高血压大鼠中，观察到血压参数显著降低。该提取物通过抑制细胞外Ca2+内流，对用肾上腺素或氯化钾预收缩的主动脉产生血管舒张作用。
结论
本研究表明，月桂水提取物通过抑制Ca2+内流，表现出强大的降压和血管舒张活性。
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