香薄荷醇对大鼠的血管舒张和降压作用：一种体外和体内研究方法。
Vasorelaxant and Antihypertensive Effects of Mentha pulegium L. in Rats: An In vitro and In vivo Approach.
机构信息
Department of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco.
出版信息
Endocr Metab Immune Disord Drug Targets. 2021;21(7):1289-1299. doi: 10.2174/1871530320666200909093908.
UNLABELLED
Aims The aim of the study was to investigate the effect of aqueous aerial part extract of Mentha pulegium L. (Pennyrile) (MPAE) on arterial pressure parameters in rats.
BACKGROUND
Mentha pulegium is a medicinal plant used to treat hypertension in the Moroccon population.
METHODS
In the current study, MPAE was prepared and its antihypertensive activity was pharmacologically investigated. L-NAME-hypertensive and normotensive rats received MPAE (180 and 300 mg/kg) orally for six hours for acute experiment and during seven days for the sub-chronic treatment. Thereafter, systolic, diastolic, mean arterial blood pressure and heart rate were evaluated. In the in vitro experiment, isolated denuded and intact thoracic aortic rings were suspended in a tissue bath system and the tension changes were recorded.
RESULTS
A fall in blood pressure was observed in L-NAME-induced hypertensive treated with MPAE. The extract also produced a dose-dependent relaxation of aorta pre-contracted with NE and KCl. The study showed that the vasorelaxant ability of MPAE seems to be exerted through the blockage of extracellular Ca entry.
CONCLUSION
The results demonstrate that the extract of pennyrile exhibits antihypertensive activity. In addition, the effect may be, at least in part, due to the dilation of blood vessels via blockage of Ca channels.
未标注
目的 本研究旨在探讨蓬蒿（Pennyrile）水提物对大鼠动脉血压参数的影响。
背景
蓬蒿是一种药用植物，在摩洛哥人群中用于治疗高血压。
方法
在本研究中，制备了蓬蒿水提物，并对其降压活性进行了药理学研究。L-NAME 高血压和正常血压大鼠分别给予 MPAE（180 和 300mg/kg）口服，急性实验持续 6 小时，亚慢性治疗持续 7 天。然后评估收缩压、舒张压、平均动脉压和心率。在离体实验中，将去内皮和完整的胸主动脉环悬挂在组织浴系统中，并记录张力变化。
结果
在 L-NAME 诱导的高血压大鼠中，MPAE 可降低血压。该提取物还可剂量依赖性地松弛 NE 和 KCl 预收缩的主动脉。研究表明，MPAE 的血管舒张能力似乎是通过阻断细胞外 Ca 内流来发挥作用的。
结论
结果表明，Pennyrile 提取物具有降压活性。此外，这种作用至少部分可能是通过阻断 Ca 通道来扩张血管所致。
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