Stutman H R, Shalit I, Marks M I, Greenwood R, Chartrand S A, Hilman B C
Am J Med. 1987 Apr 27;82(4A):142-5.
Twenty-nine adult patients with cystic fibrosis received 750 or 1,000 mg of ciprofloxacin orally every 12 hours for two weeks. Pharmacokinetic data were collected on Days 1, 7, and 14. Pharmacokinetic analyses revealed minor differences between the dosage regimens, and results were similar on the first, seventh, and last day of therapy. Means for peak serum concentration (3.1 to 5.0 micrograms/ml), elimination half-life (4.8 to 5.3 hours), area under the time-concentration curve, and serum clearance (36.8 to 44.5 liter/hour) were similar to previously reported results for patients without cystic fibrosis. Sputum concentrations approximated serum values.
29名成年囊性纤维化患者每12小时口服750毫克或1000毫克环丙沙星，持续两周。在第1天、第7天和第14天收集药代动力学数据。药代动力学分析显示不同给药方案之间存在微小差异，治疗第1天、第7天和最后一天的结果相似。血清峰浓度（3.1至5.0微克/毫升）、消除半衰期（4.8至5.3小时）、时间-浓度曲线下面积和血清清除率（36.8至44.5升/小时）的平均值与先前报道的非囊性纤维化患者的结果相似。痰液浓度接近血清值。
