Parish L C, Asper R
Am J Med. 1987 Apr 27;82(4A):227-9.
A prospective, double-blind, randomized study of hospitalized patients with skin and skin structure infections was conducted to compare orally administered ciprofloxacin and conventional intravenous cefotaxime therapy. Fifty-six patients, predominantly elderly women, were randomly assigned to receive either ciprofloxacin (24 patients, 25 infected sites) or cefotaxime (32 patients, 36 sites). Patients in the ciprofloxacin group received 750 mg of orally administered ciprofloxacin every 12 hours plus a placebo infusion while the other group received 2.0 g of cefotaxime intravenously every eight hours plus a placebo tablet every 12 hours. The average duration of treatment was seven to 10 days, with a maximum of 21 days. Clinical response per infected site in the ciprofloxacin group was as follows: resolution in 88 percent, improvement in 8 percent, and failure in 4 percent. In the cefotaxime group, there was resolution in 69 percent, improvement in 25 percent and failure in 6 percent. Bacteriologic response per site in the ciprofloxacin group was eradication in 88 percent and persistence in 12 percent. With cefotaxime there was 69 percent eradication, 3 percent marked reduction, 6 percent recurrence, and 22 percent persistence. Clinical and bacteriologic responses were combined using an algorithm to derive a cure rate, which was 91 percent for ciprofloxacin and 61 percent for cefotaxime (p = 0.0214).
对住院的皮肤和皮肤结构感染患者进行了一项前瞻性、双盲、随机研究，以比较口服环丙沙星与传统静脉注射头孢噻肟的治疗效果。56名患者（主要为老年女性）被随机分配接受环丙沙星治疗（24例患者，25个感染部位）或头孢噻肟治疗（32例患者，36个部位）。环丙沙星组患者每12小时口服750mg环丙沙星并输注安慰剂，而另一组每8小时静脉注射2.0g头孢噻肟并每12小时服用一片安慰剂。平均治疗持续时间为7至10天，最长21天。环丙沙星组每个感染部位的临床反应如下：88%痊愈，8%改善，4%治疗失败。在头孢噻肟组中，69%痊愈，25%改善，6%治疗失败。环丙沙星组每个部位的细菌学反应为88%根除，12%持续存在。使用头孢噻肟时，根除率为69%，显著降低率为3%，复发率为6%，持续存在率为22%。通过一种算法将临床和细菌学反应结合起来得出治愈率，环丙沙星的治愈率为91%，头孢噻肟为61%（p = 0.0214）。
