Ophthalmology Department of the First Affiliated Hospital of Dalian Medical University, Dalian City, Liaoning Province, China.
Ophthalmology Department of the Second Affiliated Hospital of Dalian Medical University, Dalian City, Liaoning Province, China.
Medicine (Baltimore). 2022 May 6;101(18):e29191. doi: 10.1097/MD.0000000000029191.
This meta-analysis aimed to identify the therapeutic effect of 0.01% atropine with orthokeratology on ocular axial elongation for myopia children.
We searched PubMed, Cochrane Library, and CBM databases from inception to July 1st, 2021. Meta-analysis was conducted using STATA version 14.0 and Review Manager version 5.3 softwares. We calculated the weighted mean differences to analyze the change of ocular axial length (AL) between orthokeratology combined with 0.01% atropine (OKA) and) alone. The Cochran's Q-statistic and I2 test were used to evaluate potential heterogeneity between studies. To evaluate the influence of single studies on the overall estimate, a sensitivity analysis was performed. We also performed sub group and meta-regression analyses to investigate potential sources of heterogeneity. We conducted Begger funnel plots and Egger linear regression tests to investigate publication bias.
Nine studies that met all inclusion criteria were included in this meta-analysis. A total of 191 children in OKA group and 196 children in orthokeratology (OK) group were assessed. The pooled summary weighted mean differences of AL change was -0.90 (95% CI = -1.25-0.55) with statistical significance (t = -5.03, P < .01), which indicated there was obvious difference between OKA and OK in myopic children. Subgroup analysis also showed that OKA treatment resulted in significantly less axial elongation compared to OK treatment alone according to SER. We found no evidence for publication bias.
Our meta-analysis indicates 0.01% atropine atropine is effective in slowing axial elongation in myopia children with orthokeratology.
本荟萃分析旨在确定 0.01%阿托品与角膜塑形术联合治疗近视儿童眼轴伸长的疗效。
我们检索了 PubMed、Cochrane 图书馆和 CBM 数据库，检索时间截至 2021 年 7 月 1 日。使用 STATA 版本 14.0 和 Review Manager 版本 5.3 软件进行荟萃分析。我们计算了加权均数差值来分析角膜塑形术联合 0.01%阿托品（OKA）与单纯角膜塑形术（OK）之间眼轴长度（AL）的变化。采用 Cochran's Q 统计量和 I 2 检验评估研究间的潜在异质性。为评估单个研究对总体估计的影响，进行了敏感性分析。我们还进行了亚组和荟萃回归分析，以探讨潜在的异质性来源。我们进行了 Begger 漏斗图和 Egger 线性回归检验，以评估发表偏倚。
共有 9 项符合所有纳入标准的研究被纳入本荟萃分析。OKA 组共纳入 191 例儿童，OK 组共纳入 196 例儿童。AL 变化的汇总加权均数差值为-0.90（95%CI=-1.25-0.55），差异有统计学意义（t=-5.03，P<.01），表明 OKA 组与 OK 组在近视儿童中存在明显差异。亚组分析还显示，根据 SER，OKA 治疗与单独 OK 治疗相比，眼轴伸长明显减少。我们未发现发表偏倚的证据。
本荟萃分析表明，0.01%阿托品在角膜塑形术治疗近视儿童中能有效减缓眼轴伸长。
