生殖中心 B 细胞中的 3D 染色体结构及其在淋巴瘤发生中的改变。
3D chromosomal architecture in germinal center B cells and its alterations in lymphomagenesis.
机构信息
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
出版信息
Curr Opin Genet Dev. 2022 Jun;74:101915. doi: 10.1016/j.gde.2022.101915. Epub 2022 May 9.
In eukaryotic cells, the genome is three dimensionally (3D) organized with DNA interaction dynamics and topology changes that regulate gene expression and drive cell fate. Upon antigen stimulation, naive B cells are activated and form germinal centers (GC) for the generation of memory B cells and plasma cells. Thereby, terminal B-cell differentiation and associated humoral immune response require massive but rigorous 3D DNA reorganization. Here, we review the dynamics of genome reorganization during GC formation and the impact of its alterations on lymphomagenesis from the nucleosome structure to the higher order chromosome organization. We particularly discuss the identified architects of 3D DNA in GC B cells and the role of their mutations in B-cell lymphomas.
在真核细胞中，基因组通过 DNA 相互作用动力学和拓扑结构变化进行三维（3D）组织，这些变化调节基因表达并驱动细胞命运。抗原刺激后，初始 B 细胞被激活并形成生发中心（GC），以产生记忆 B 细胞和浆细胞。因此，终末 B 细胞分化和相关的体液免疫反应需要大规模但严格的 3D DNA 重组。在这里，我们综述了 GC 形成过程中基因组重组的动态以及其改变对从核小体结构到更高阶染色体组织的淋巴瘤发生的影响。我们特别讨论了在 GC B 细胞中鉴定出的 3D DNA 架构及其突变在 B 细胞淋巴瘤中的作用。
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