二氢杨梅素设计的自微乳给药系统及其对高脂饮食喂养小鼠的膳食干预作用。
A designed self-microemulsion delivery system for dihydromyricetin and its dietary intervention effect on high-fat-diet fed mice.
机构信息
College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang 524088, China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.
College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang 524088, China.
出版信息
Food Chem. 2022 Oct 1;390:132954. doi: 10.1016/j.foodchem.2022.132954. Epub 2022 Apr 11.
The present study aims to design a self-microemulsion delivery system (d-α-tocopheryl polyethylene glycol 1000 succinate - quillaja saponin) to enhance the absorptivity of dihydromyricetin (DMY-S), and to investigate its dietary intervention effect on high-fat-diet (HFD) fed mice. We find DMY-S can inhibit the increase of body weight and fat mass, preventing non-alcoholic fatty liver disease. Compared to the model group, the abundance of mice intestinal flora is mainly changed in certain bacterial genera of Firmicutes and Bacteroides, including norank_f_Muribaculaceae and Blautia. The result of metabolism analysis indicated that the expression levels of cincassiol B, creatine, pantothenic acid and aminobutyric acid in the liver tissues of mice treated with DMY-S showed a down-regulation. The DMY-S prevented hyperlipidemia in HFD mice mainly by affecting different pathways including glycerophospholipid metabolism, sphingolipid metabolism and pantothenate and CoA biosynthesis.
本研究旨在设计一种自微乳给药系统（d-α-生育酚聚乙二醇 1000 琥珀酸酯-皂树皮皂苷），以提高二氢杨梅素（DMY-S）的吸收率，并研究其对高脂肪饮食（HFD）喂养小鼠的饮食干预作用。我们发现 DMY-S 可以抑制体重和脂肪量的增加，预防非酒精性脂肪肝疾病。与模型组相比，DMY-S 处理的小鼠肠道菌群的丰度主要在厚壁菌门和拟杆菌门的某些细菌属中发生变化，包括 norank_f_Muribaculaceae 和 Blautia。代谢分析的结果表明，DMY-S 处理的小鼠肝组织中 cincassiol B、肌酸、泛酸和氨基丁酸的表达水平呈下调趋势。DMY-S 通过影响甘油磷脂代谢、鞘脂代谢和泛酸和 CoA 生物合成等不同途径，主要防止 HFD 小鼠发生高脂血症。
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