Xia Tian, Zhu Runzhi
National Clinical Research Center for Child Health, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, P.R. China.
Biomed Rep. 2024 Mar 26;20(5):82. doi: 10.3892/br.2024.1769. eCollection 2024 May.
Dihydromyricetin (DHM) is a natural flavonoid compound with multiple antitumour effects, including inhibition of proliferation, promotion of apoptosis, inhibition of invasion and migration, clearance of reactive oxygen species (ROS) and induction of autophagy. For example, DHM can effectively block the progression of the tumour cell cycle and inhibit cell proliferation. In different types of cancer cells, DHM can regulate the PI3K/Akt pathway, mTOR, and NF-κB pathway components, such as p53, and endoplasmic reticulum stress can alter the accumulation of ROS or induce autophagy to promote the apoptosis of tumour cells. In addition, when DHM is used in combination with various known chemotherapy drugs, such as paclitaxel, nedaplatin, doxorubicin, oxaliplatin and vinblastine, it can increase the sensitivity of tumour cells to DHM and increase the therapeutic effect of chemotherapy drugs. In the present review, the multiple molecular and cellular mechanisms underlying the antitumour effect of DHM, as well as its ability to increase the effects of various traditional antitumour drugs were summarized. Through the present review, it is expected by the authors to draw attention to the potential of DHM as an antitumour drug and provide valuable references for the clinical translation of DHM research and the development of related treatment strategies.
二氢杨梅素（DHM）是一种具有多种抗肿瘤作用的天然黄酮类化合物，包括抑制增殖、促进凋亡、抑制侵袭和迁移、清除活性氧（ROS）以及诱导自噬。例如，DHM可有效阻断肿瘤细胞周期进程并抑制细胞增殖。在不同类型的癌细胞中，DHM可调节PI3K/Akt通路、mTOR和NF-κB通路成分，如p53，内质网应激可改变ROS的积累或诱导自噬以促进肿瘤细胞凋亡。此外，当DHM与各种已知的化疗药物联合使用时，如紫杉醇、奈达铂、阿霉素、奥沙利铂和长春碱，它可增加肿瘤细胞对DHM的敏感性并提高化疗药物的治疗效果。在本综述中，总结了DHM抗肿瘤作用的多种分子和细胞机制，以及其增强各种传统抗肿瘤药物疗效的能力。通过本综述，作者期望引起人们对DHM作为抗肿瘤药物潜力的关注，并为DHM研究的临床转化和相关治疗策略的开发提供有价值的参考。
