Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Swiss Institute for Bioinformatics, University of Lausanne, Lausanne, Switzerland.
Nucleic Acids Res. 2022 Jul 5;50(W1):W623-W632. doi: 10.1093/nar/gkac330.
The Orthology Benchmark Service (https://orthology.benchmarkservice.org) is the gold standard for orthology inference evaluation, supported and maintained by the Quest for Orthologs consortium. It is an essential resource to compare existing and new methods of orthology inference (the bedrock for many comparative genomics and phylogenetic analysis) over a standard dataset and through common procedures. The Quest for Orthologs Consortium is dedicated to maintaining the resource up to date, through regular updates of the Reference Proteomes and increasingly accessible data through the OpenEBench platform. For this update, we have added a new benchmark based on curated orthology assertion from the Vertebrate Gene Nomenclature Committee, and provided an example meta-analysis of the public predictions present on the platform.
同源基准服务(https://orthology.benchmarkservice.org)是同源推断评估的黄金标准,由同源搜索联盟支持和维护。它是比较现有和新的同源推断方法的重要资源(许多比较基因组学和系统发育分析的基础),通过标准数据集和常见程序进行比较。同源搜索联盟致力于通过定期更新参考蛋白质组和通过 OpenEBench 平台提供越来越容易访问的数据来保持资源的最新。此次更新,我们添加了一个新的基准,基于脊椎动物基因命名委员会的精心整理的同源断言,并提供了平台上公开预测的示例元分析。