Morrison D C, Ryan J L
Annu Rev Med. 1987;38:417-32. doi: 10.1146/annurev.me.38.020187.002221.
In this chapter, current concepts about the mechanisms of action of endotoxin are reviewed. Particular attention is focused upon endotoxin-induced production of soluble mediators from macrophages and mononuclear cells and on the potential contribution of these mediators to endotoxin shock. In many cases, the interrelationships between these mediators as primary and/or secondary consequences of endotoxin stimulation of mononuclear phagocytes are discussed. Final comments address the relevance of these mediators to the therapy of endotoxin shock.
在本章中，我们将综述目前关于内毒素作用机制的概念。特别关注内毒素诱导巨噬细胞和单核细胞产生可溶性介质，以及这些介质对内毒素休克的潜在影响。在许多情况下，我们还将讨论这些介质之间作为内毒素刺激单核吞噬细胞的主要和/或次要后果的相互关系。最后，我们将阐述这些介质与内毒素休克治疗的相关性。
