Beutler B
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas.
New Horiz. 1993 Feb;1(1):3-12.
For some time, it has been clear that septic shock results from the coordinated release of cytokine mediators that directly or indirectly injure tissues of the host. Natural and synthetic inhibitors of tumor necrosis factor, interleukin-1, and other key cytokines may alter current concepts regarding shock and its therapy.