Chakhava O V
Antibiot Med Biotekhnol. 1987 Mar;32(3):170-3.
Gnotobiological studies showed that under natural conditions normal microflora (microsymbiocenosis) is necessary for normal vital activity. In addition to autochthonous flora microsymbiocenosis includes an insignificant number of facultative pathogenic bacteria. In etiotropic antibiotic therapy it is important to preserve the autochthonous portion of the microsymbiocenonosis: bifidobacteria, lactobacilli, propionic bacteria and others. However, with respect to certain indications (diseases associated with suppression of resistance to infections) total decontamination with obligatory isolation of the patient under gnotobiological conditions is possible. In selective decontamination the facultative pathogenic portion of the intestinal microflora is the sole target of antibiotics. Selective decontamination is one of the methods for control of nosocomial infections, dysbacteriosis. It is indicated that establishment of departments in charge of investigation of intestinal microflora of patients and medical staff in hospitals is required for detecting risk groups which can be both the source of infection and the population most susceptible to hospital strains of antibiotic resistant facultative pathogenic bacteria.
悉生生物学研究表明，在自然条件下，正常微生物群（微共生群落）对于正常生命活动是必需的。除了本土菌群外，微共生群落还包括数量极少的兼性病原菌。在病因性抗生素治疗中，保留微共生群落的本土部分很重要：双歧杆菌、乳酸杆菌、丙酸杆菌等。然而，对于某些适应症（与感染抵抗力抑制相关的疾病），在悉生生物学条件下对患者进行强制性隔离并彻底净化是可行的。在选择性净化中，肠道微生物群的兼性致病部分是抗生素的唯一目标。选择性净化是控制医院感染、菌群失调的方法之一。有人指出，医院需要设立负责调查患者和医务人员肠道微生物群的部门，以检测可能既是感染源又是最易感染耐抗生素兼性病原菌医院菌株人群的风险群体。
