Hood A F, Vogelsang G B, Black L P, Farmer E R, Santos G W
Arch Dermatol. 1987 Jun;123(6):745-50. doi: 10.1001/archderm.123.6.745.
Graft-vs-host disease (GVHD) is a frequent complication of allogeneic bone marrow transplantation but has been infrequently reported following autologous or syngeneic bone marrow transplantation. Ninety-six autologous and 19 syngeneic marrow transplants were performed at our institution between July 1977 and March 1984. We report acute cutaneous GVHD occurring in seven patients who received autologous marrow and two patients who received marrow from an identical twin. All nine patients had clinically detectable eruptions and had skin biopsy specimens with histologic changes of grade 2 acute GVHD. Although most cases were mild and self-limiting, four patients required systemic corticosteroids to treat their disease. Thus, acute cutaneous GVHD was seen in approximately 8% of patients receiving autologous or syngeneic bone marrow transplants at our institution.
移植物抗宿主病（GVHD）是同种异体骨髓移植常见的并发症，但自体或同基因骨髓移植后较少报道。1977年7月至1984年3月期间，我们机构进行了96例自体和19例同基因骨髓移植。我们报告了7例接受自体骨髓移植和2例接受同卵双胞胎骨髓移植的患者发生急性皮肤GVHD。所有9例患者临床上均有可检测到的皮疹，皮肤活检标本有2级急性GVHD的组织学改变。尽管大多数病例为轻度且自限性，但4例患者需要全身使用皮质类固醇治疗其疾病。因此，在我们机构接受自体或同基因骨髓移植的患者中，约8%出现了急性皮肤GVHD。
