Martin R W, Farmer E R, Altomonte V L, Vogelsang G B, Santos G W
Department of Dermatology, Johns Hopkins University, School of Medicine, Baltimore, Md.
Arch Dermatol. 1995 Mar;131(3):333-5.
Graft-vs-host disease (GVHD) represents one of the major complications of allogeneic bone marrow transplantation (BMT) but is less common in autologous BMT. Following autologous BMT, chronic GVHD has been reported in only four patients, all of whom had a self-limited sclerodermoid form. Lichenoid chronic GVHD has not been previously reported in an autologous BMT patient.
Mucosal and cutaneous lichenoid lesions and histologic findings compatible with chronic lichenoid GVHD developed in a patient 35 days after autologous BMT was performed. The onset of clinical lesions at 35 days after BMT is not incongruent with the diagnosis of chronic lichenoid GVHD (rather than a graft-vs-host reaction) and may have been augmented by cyclosporin A in a manner similar to animal model experiments.
All forms of GVHD can and do occur following autologous BMT.
移植物抗宿主病（GVHD）是异基因骨髓移植（BMT）的主要并发症之一，但在自体BMT中较少见。自体BMT后，仅报道过4例慢性GVHD患者，均为自限性硬皮病样表现。此前尚无自体BMT患者发生苔藓样慢性GVHD的报道。
1例患者在自体BMT后35天出现黏膜和皮肤苔藓样病变及与慢性苔藓样GVHD相符的组织学表现。BMT后35天出现临床病变与慢性苔藓样GVHD（而非移植物抗宿主反应）的诊断并不矛盾，且可能因环孢素A以类似于动物模型实验的方式而加重。
自体BMT后可发生各种形式的GVHD。
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