Odberg F O, Kennes D, De Rycke P H, Bouquet Y
Arch Int Pharmacodyn Ther. 1987 Jan;285(1):34-42.
The level of the captivity-induced jumping stereotypy in bank voles was significantly decreased by 150 and 200 mg/kg alpha-methyl-para-tyrosine and increased by 200 mg/kg L-DOPA while 20 and 40 mg/kg fusaric acid had no effect. None of the other movements were affected by these drugs (as measured by a general activity meter), except for a nonsignificant decrease after treatment with fusaric acid. These results suggest that cerebral dopaminergic neuronal systems and not noradrenergic neuronal systems are involved in the expression of that stereotypy in bank voles.
150毫克/千克和200毫克/千克的α-甲基-对-酪氨酸显著降低了笼养引发的田鼠跳跃刻板行为的水平，而200毫克/千克的左旋多巴则使其增加，而20毫克/千克和40毫克/千克的镰刀菌酸没有影响。除了用镰刀菌酸处理后有不显著的减少外，这些药物对其他运动均无影响（通过一般活动计测量）。这些结果表明，脑多巴胺能神经元系统而非去甲肾上腺素能神经元系统参与了田鼠那种刻板行为的表达。
