Kennes D, Odberg F O, Bouquet Y, De Rycke P H
State University of Ghent, Laboratory of Zoophysiology, Belgium.
Eur J Pharmacol. 1988 Aug 9;153(1):19-24. doi: 10.1016/0014-2999(88)90583-3.
Captivity-induced stereotypies in bank voles (Clethrionomys glareolus) were inhibited at the age of 1, 2, 4, 6, 8 and 10 months by 0.2 mg/kg haloperidol s.c., while 35 mg/kg naloxone s.c. only inhibited them at the age of 4-6 months. Other activities were not significantly inhibited. The change in the naloxone effect was not due to desensitization as animals treated only at 6 or 8 months reacted similarly. It is suggested that the expression of such stereotypies is influenced by endogeneous brain opioid peptides during an early stage of their development, but that thereafter only motoric automatisms remain, essentially under dopaminergic control.
在1、2、4、6、8和10月龄时，0.2mg/kg的氟哌啶醇皮下注射可抑制圈养诱导的小林姬鼠（Clethrionomys glareolus）刻板行为，而35mg/kg的纳洛酮皮下注射仅在4 - 6月龄时抑制刻板行为。其他活动未受到显著抑制。纳洛酮作用的变化并非由于脱敏，因为仅在6或8月龄接受治疗的动物反应相似。研究表明，此类刻板行为的表达在其发育早期受内源性脑阿片肽影响，但此后仅运动自动行为留存，主要受多巴胺能控制。
