Shaw J H, Wolfe R R
Aust N Z J Surg. 1987 Jan;57(1):41-7. doi: 10.1111/j.1445-2197.1987.tb01238.x.
Energy and protein metabolism in septic and trauma patients has been extensively studied over the past 30 years. Despite this, a number of inconsistencies are present in the literature and it is difficult to formulate a clear global picture of this complex series of metabolic events. Conclusions from human studies have often been hampered by the utilization of small numbers of patients, and data from animal models of sepsis or trauma are often difficult to interpret. Over the past 5 years, the authors have performed a series of isotopic infusions in normal volunteers, and in patients with either sepsis or trauma, in order to gain a clearer understanding of energy and protein metabolism in severely stressed patients. This review summarizes the findings.
在过去30年里，人们对脓毒症和创伤患者的能量及蛋白质代谢进行了广泛研究。尽管如此，文献中仍存在一些不一致之处，难以勾勒出这一系列复杂代谢事件的清晰全貌。人体研究的结论常常因患者数量较少而受到限制，脓毒症或创伤动物模型的数据也往往难以解读。在过去5年里，作者对正常志愿者、脓毒症患者或创伤患者进行了一系列同位素输注，以便更清楚地了解重症应激患者的能量和蛋白质代谢。本综述总结了这些研究结果。
