Yeh Chun-Chang, Chiu Chong-Chi, Wang Jhi-Joung, Chou An-Kuo, Chen Yu-Wen, Zhu Guan-Cheng, Hung Ching-Hsia
Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Pharmacol Rep. 2022 Jun;74(3):470-480. doi: 10.1007/s43440-022-00368-x. Epub 2022 May 13.
The purpose of the study was to investigate spinal sensory and motor block by antiparkinsonian drugs (pramipexole and selegiline), and the combination of pramipexole and the local anesthetic lidocaine.
Using a technique of spinal blockade in rats, the effects of pramipexole, selegiline, and coadministration of pramipexole and lidocaine on spinal blockades of motor and sensory function were investigated.
Under a concentration of 100 mM, pramipexole displayed more potent and had a longer duration of nociceptive, proprioceptive, and motor block than selegiline, whereas pramipexole and selegiline were less potent in comparison to lidocaine. Pramipexole produced spinal nociceptive, proprioceptive, and motor blocks in a dose-related manner. On the ED (50% effective dose) basis, the rank-order potency on nociceptive, proprioceptive, and motor block was pramipexole < lidocaine. The spinal block duration of pramipexole was greater than lidocaine at every equipotent dose tested (ED, ED, and ED). Coadministration of lidocaine (ED or ED) with pramipexole (4.5 μmol/kg) improved the effect (efficacy) and duration of the spinal block.
Pramipexole and selegiline were less potent than lidocaine to block sensory and motor responses. The duration of the spinal anesthetic effect of pramipexole was longer than lidocaine. At a non-effective dose, pramipexole increased the duration of efficacy of lidocaine.
本研究旨在探讨抗帕金森病药物（普拉克索和司来吉兰）以及普拉克索与局部麻醉药利多卡因联合使用对脊髓感觉和运动阻滞的影响。
采用大鼠脊髓阻滞技术，研究普拉克索、司来吉兰以及普拉克索与利多卡因联合使用对运动和感觉功能脊髓阻滞的影响。
在100 mM浓度下，普拉克索比司来吉兰具有更强且持续时间更长的伤害性、本体感觉和运动阻滞作用，而与利多卡因相比，普拉克索和司来吉兰的作用较弱。普拉克索产生的脊髓伤害性、本体感觉和运动阻滞呈剂量相关。以ED（50%有效剂量）为基础，在伤害性、本体感觉和运动阻滞方面的效价顺序为普拉克索＜利多卡因。在每个测试的等效剂量（ED、ED和ED）下，普拉克索的脊髓阻滞持续时间均长于利多卡因。利多卡因（ED或ED）与普拉克索（4.5 μmol/kg）联合使用可改善脊髓阻滞的效果（效能）和持续时间。
普拉克索和司来吉兰在阻断感觉和运动反应方面的效力低于利多卡因。普拉克索的脊髓麻醉作用持续时间长于利多卡因。在无效剂量下，普拉克索可延长利多卡因的效能持续时间。
