Chestnutt W N, Clarke R S, Dundee J W
Br J Anaesth. 1987 May;59(5):576-80. doi: 10.1093/bja/59.5.576.
In a randomized double-blind placebo-controlled trial involving 80 patients nalbuphine 10 mg and 20 mg were compared with pethidine 100 mg and a placebo given i.m. at least 90 min before minor gynaecological surgery. Nalbuphine proved a suitable alternative to pethidine, producing beneficial sedation which was maximum at 60 min after injection. Both nalbuphine and pethidine reduced the excitatory sequelae of methohexitone induction. Increasing the dose of nalbuphine from 10 mg to 20 mg produced no significant additional sedation or intraoperative benefit. Short-lived pain at the injection site was a feature of the use of nalbuphine in either dose. The main disadvantage of nalbuphine was nausea and vomiting of delayed onset, the frequency of which was similar after either dose.
在一项涉及80名患者的随机双盲安慰剂对照试验中，将10毫克和20毫克纳布啡与100毫克哌替啶及安慰剂进行比较，于妇科小手术前至少90分钟肌肉注射给药。结果证明，纳布啡是哌替啶的合适替代药物，能产生有益的镇静作用，在注射后60分钟时达到最大效果。纳布啡和哌替啶均能减轻美索比妥诱导的兴奋后遗症。将纳布啡剂量从10毫克增至20毫克并未产生显著额外的镇静作用或术中益处。两种剂量的纳布啡使用时均有注射部位短暂疼痛的特点。纳布啡的主要缺点是恶心和呕吐延迟发作，两种剂量后的发生频率相似。
