Brock-Utne J G, Ritchie P, Downing J W
S Afr Med J. 1985 Sep 14;68(6):391-3.
Nalbuphine hydrochloride (Nubain; Du Pont Pharmaceuticals), a synthetic agonist-antagonist analgesic, in a dose of 20 mg was compared with pethidine 100 mg in 60 patients after elective surgery in a random double-blind study. Both drugs were given intramuscularly on the first day after surgery. The pain intensity and visual analogue scales would seem to indicate that nalbuphine has a longer duration of action than pethidine (P less than 0,05). The respiration rates in the pethidine group were significantly more depressed 30 minutes after the injection than in the nalbuphine group (P less than 0,05). Nalbuphine caused less depression of both systolic and diastolic blood pressure at both 30 and 60 minutes (P less than 0,001). The results of the study show that nalbuphine, in the dose used here, may prove to be a useful substitute for pethidine.
在一项随机双盲研究中，将60例择期手术后的患者使用20毫克剂量的盐酸纳布啡（Nubain；杜邦制药公司）这种合成激动 - 拮抗型镇痛药与100毫克哌替啶进行了比较。两种药物均在术后第一天肌肉注射。疼痛强度和视觉模拟量表似乎表明，纳布啡的作用持续时间比哌替啶更长（P小于0.05）。注射后30分钟，哌替啶组的呼吸频率明显比纳布啡组更受抑制（P小于0.05）。在30分钟和60分钟时，纳布啡对收缩压和舒张压的降低作用均较小（P小于0.001）。研究结果表明，此处使用剂量的纳布啡可能被证明是哌替啶的一种有用替代品。
