Kuijpers M H, de Jong W
Br J Exp Pathol. 1987 Apr;68(2):179-87.
The fawn-hooded rat (FH rat) develops hypertension accompanied with focal and segmental glomerulosclerosis and proteinuria, resulting in premature death. In a first experiment the relationship between renal lesions and blood pressure at various ages was investigated. In a second experiment blood pressure was measured weekly from 10 to 38 weeks of age in a number of male FH rats, followed by examination of renal tissues at 40 weeks of age. Plasma renin activity (PRA) had also been determined in individual FH rats. FH rats aged 4.5 weeks had no renal morphological abnormalities. The severity of the glomerulosclerosis increased with age and showed a positive relationship with blood pressure. The scores of the proteinaceous tubular casts also increased with age and they, too, showed a positive correlation with blood pressure. The severity of glomerulosclerosis and proteinaceous casts at 40 weeks of age was related positively to the course of blood pressure throughout life. The final blood pressure level showed a positive correlation with final PRA values. Only FH rats with malignant nephrosclerosis had high PRA values. The renal glomerular and vascular lesions in the FH rat, most likely caused by the hypertension, progressively deteriorate to malignant nephrosclerosis. At that stage PRA values are increased and may be contributing to the development of renal vascular lesions and acceleration of the hypertension.
小鹿斑鼠（FH大鼠）会出现高血压，并伴有局灶节段性肾小球硬化和蛋白尿，最终导致过早死亡。在第一个实验中，研究了不同年龄阶段肾脏病变与血压之间的关系。在第二个实验中，对若干雄性FH大鼠从10周龄到38周龄每周测量血压，然后在40周龄时检查肾脏组织。还测定了每只FH大鼠的血浆肾素活性（PRA）。4.5周龄的FH大鼠没有肾脏形态学异常。肾小球硬化的严重程度随年龄增加，且与血压呈正相关。蛋白管型的评分也随年龄增加，并且它们也与血压呈正相关。40周龄时肾小球硬化和蛋白管型的严重程度与一生的血压病程呈正相关。最终血压水平与最终PRA值呈正相关。只有患有恶性肾硬化的FH大鼠具有高PRA值。FH大鼠的肾小球和血管病变很可能是由高血压引起的，会逐渐恶化为恶性肾硬化。在那个阶段，PRA值升高，可能会导致肾血管病变的发展和高血压的加速。
