Ristow H J, Holley R W, Messmer T O
J Invest Dermatol. 1978 Jul;71(1):18-23. doi: 10.1111/1523-1747.ep12543767.
Present knowledge on regulation of fibroblast growth is based on in vitro culture of fibroblasts from different sources. The research has focused on 2 problems: identification of the signal that reaches the fibroblast from outside and tells it to grow and identification of metabolic reactions inside the cell that commit it to initiate DNA synthesis after the signal arrives. Although the signal and the metabolic reactions have not yet been clearly identified, and the relationship between in vivo conditions and the result of these in vitro studies still has to be determined, the large body of data collected so far and the steadily growing information concerning these problems suggest a complex interrelation between cellular environment and metabolic processes involved in growth regulation.
目前关于成纤维细胞生长调节的知识是基于对来自不同来源的成纤维细胞进行体外培养。该研究集中在两个问题上：一是识别从外部到达成纤维细胞并使其生长的信号，二是识别细胞内的代谢反应，这些反应在信号到达后促使细胞开始DNA合成。尽管信号和代谢反应尚未明确识别，且体内条件与这些体外研究结果之间的关系仍有待确定，但迄今为止收集的大量数据以及关于这些问题的不断增加的信息表明，细胞环境与生长调节中涉及的代谢过程之间存在复杂的相互关系。
