Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301608, China.
Department of Digestive Diseases, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China.
J Zhejiang Univ Sci B. 2022 May 15;23(5):353-364. doi: 10.1631/jzus.B2101055.
Vascular endothelial growth factor (VEGF) is the main regulator of physiological angiogenesis during embryonic development, bone growth, and reproductive function, and it also participates in a series of pathological changes. Traditional Chinese medicine (TCM), with a history of more than 2000 years, has been widely used in clinical practice, while the exploration of its mechanisms has only begun. This review summarizes the research of recent years on the influence of TCM on VEGF. It is found that many Chinese medicines and recipes have a regulatory effect on VEGF, indicating that Chinese medicine has broad prospects as a complementary and alternative therapy, providing new treatment ideas for clinical applications and the theoretical basis for research on the mechanisms of TCM.
血管内皮生长因子(VEGF)是胚胎发育、骨骼生长和生殖功能中生理性血管生成的主要调节因子,它也参与了一系列的病理变化。中医药(TCM)已有 2000 多年的历史,已广泛应用于临床实践,而对其机制的探索才刚刚开始。本综述总结了近年来关于 TCM 对 VEGF 影响的研究。研究发现,许多中药和方剂对 VEGF 具有调节作用,这表明中药作为一种补充和替代疗法具有广阔的前景,为临床应用提供了新的治疗思路,并为中医药机制的研究提供了理论依据。