Center for Cancer & Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China.
Planta Med. 2010 Aug;76(11):1118-31. doi: 10.1055/s-0030-1250186. Epub 2010 Jul 15.
Traditional Chinese medicine-based herbal medicines have gained increasing acceptance worldwide in recent years and are being pursued by pharmaceutical companies as rich resources for drug discovery. For many years, traditional Chinese medicines (TCM) have been applied for the treatment of cancers in China and beyond. Herbal medicines are generally low in cost, plentiful, and show very little toxicity or side effects in clinical practice. However, despite the vast interest and ever-increasing demand, the absence of strong evidence-based research and the lack of standardization of the herbal products are the main obstacles toward the globalization of TCM. In recent years, TCM research has greatly accelerated with the advancement of analytical technologies and methodologies. This review of TCM specifically used in the treatment of cancer is divided into two parts. Part one provides an overview of the philosophy, approaches and progress in TCM-based cancer therapy. Part two summarizes the current understanding of how TCM-derived compounds function as anticancer drugs.
近年来，基于中药的草药在全球范围内越来越受到认可，并被制药公司视为药物发现的丰富资源。多年来，中药（TCM）在中国及其他地区一直被用于癌症的治疗。草药通常成本低、丰富，在临床实践中显示出很少的毒性或副作用。然而，尽管人们对此非常感兴趣，需求也在不断增加，但缺乏强有力的循证研究和草药产品的标准化是阻碍 TCM 全球化的主要障碍。近年来，随着分析技术和方法的进步，TCM 研究大大加速。本综述特别针对用于癌症治疗的 TCM 进行了分类，分为两部分。第一部分概述了基于 TCM 的癌症治疗的哲学、方法和进展。第二部分总结了目前对 TCM 衍生化合物作为抗癌药物的作用机制的理解。
