Sympathetic sprouting in the central nervous system: a model for studies of axonal growth in the mature mammalian brain.

Sympathetic fibers innervate many peripheral tissues but are normally confined to extracerebral structures within the cranial cavity, e.g. blood vessels. The invasion of the central nervous system by vascular sympathetic axons is a unique example of neuronal plasticity which provides new information concerning the regulation and mechanisms of neuronal sprouting in both the peripheral and central nervous systems. In this paper, the principal findings concerning the conditions under which such sprouting occurs, the mechanisms which may be involved, and the question of its possible function are reviewed. Of special interest is the fact that a nerve growth factor-like brain factor may be involved in this growth response. The principles gleaned from studies of this sprouting phenomenon may be applicable to other models of neuronal plasticity and may have clinical relevance.