Crutcher K A, Brothers L, Davis J N
Brain Res. 1981 Apr 6;210(1-2):115-28. doi: 10.1016/0006-8993(81)90889-1.
An unusual example of neuronal sprouting occurs in the rat brain. Several weeks after fimbrial transection or septal lesions, peripheral sympathetic fibers appear in the dentate and hippocampal gyri. We compared the distribution of normal cholinergic septohippocampal fibers and nerve terminals with the distribution of noradrenergic sympathetic (sympathohippocampal) fibers after septal lesions using anterograde transport of horseradish peroxidase and fluorescence histochemistry. In addition, we destroyed other afferents to the hippocampal formation and examined the effect of subtotal septal lesions on acetylcholinesterase staining and the distribution of sympathohippocampal fibers. The combined results of these experiments suggest that peripheral noradrenergic fibers sprout specifically in response to destruction of central cholinergic fibers after septal lesions. This appears to be the first model of neuronal sprouting in the central nervous system where one identified transmitter system (noradrenergic) sprouts only in response to, and perhaps to replace, another specific transmitter system (cholinergic).
在大鼠大脑中发生了一个神经元发芽的不寻常例子。在海马伞横断或隔区损伤几周后，外周交感神经纤维出现在齿状回和海马回。我们使用辣根过氧化物酶的顺行运输和荧光组织化学，比较了正常胆碱能隔海马纤维和神经终末的分布与隔区损伤后去甲肾上腺素能交感（交感海马）纤维的分布。此外，我们破坏了海马结构的其他传入纤维，并研究了部分隔区损伤对乙酰胆碱酯酶染色和交感海马纤维分布的影响。这些实验的综合结果表明，外周去甲肾上腺素能纤维在隔区损伤后，会因中枢胆碱能纤维的破坏而特异性发芽。这似乎是中枢神经系统中神经元发芽的首个模型，其中一个已确定的递质系统（去甲肾上腺素能）仅在响应并可能替代另一个特定递质系统（胆碱能）时发芽。
