Hamilton P
Neurochirurgische Klinik, Universität Bonn, Germany.
Biol Cybern. 1993;68(6):559-65. doi: 10.1007/BF00200816.
How can biological plasticity been added to a simulation of neuritic growth? Coming from this question, we have chosen a new access to simulate neuritic growth under the very aspect of meaningful and progredient development of single cells. Based on a specific description-language, we have set up a computer-program, to construct neurite-models and to simulate neuritic interaction during their development. Instead of using mathematical equations, we define various types of cytoskeletons by taking a specified graph grammar. Using this technique, we are able to define strings, combined with other influencing parameters, which allow the setting up of very naturally behaving artificial nervecells, in which distinct statistical variance and fixed rules as given in DNA operate together. In this paper, we want to discuss the underlying principles of the given grammar and to show some results from these computer-simulations, which enable us to study growth, development and other specific characteristics of neurites within a simulator in comparison to in vivo-experiments.
如何将生物可塑性添加到神经突生长的模拟中?基于这个问题,我们选择了一种新的方法,从单细胞有意义且渐进发展的角度来模拟神经突生长。基于一种特定的描述语言,我们编写了一个计算机程序,用于构建神经突模型并模拟它们在发育过程中的相互作用。我们不是使用数学方程,而是通过采用特定的图文法来定义各种类型的细胞骨架。使用这种技术,我们能够定义与其他影响参数相结合的字符串,从而构建出行为非常自然的人工神经细胞,其中DNA中给定的不同统计方差和固定规则共同起作用。在本文中,我们将讨论给定文法的基本原理,并展示这些计算机模拟的一些结果,这些结果使我们能够在模拟器中研究神经突的生长、发育和其他特定特征,并与体内实验进行比较。