静息态功能磁共振成像的功能连接特征可能有助于鉴别偏头痛与紧张型头痛。
Functional Connectivity Features of Resting-State Functional Magnetic Resonance Imaging May Distinguish Migraine From Tension-Type Headache.
作者信息
Wang Yajuan, Wang Yingshuang, Bu Lihong, Wang Shaoyang, Xie Xinhui, Lin Fuchun, Xiao Zheman
机构信息
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Positron Emission Tomography-Computer Tomography (PET-CT)/Magnetic Resonance Imaging (MRI) Center, Renmin Hospital of Wuhan University, Wuhan, China.
出版信息
Front Neurosci. 2022 Apr 26;16:851111. doi: 10.3389/fnins.2022.851111. eCollection 2022.
BACKGROUND
Migraineurs often exhibited abnormalities in cognition, emotion, and resting-state functional connectivity (rsFC), whereas patients with tension-type headache (TTH) rarely exhibited these abnormalities. The aim of this study is to explore whether rsFC alterations in brain regions related to cognition and emotion could be used to distinguish patients with migraine from patients with TTH.
METHODS
In this study, Montreal Cognitive Assessment (MoCA), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), and rsFC analyses were used to assess the cognition, anxiety, and depression of 24 healthy controls (HCs), 24 migraineurs, and 24 patients with TTH. Due to their important roles in neuropsychological functions, the bilateral amygdala and hippocampus were chosen as seed regions for rsFC analyses. We further assessed the accuracy of the potential rsFC alterations for distinguishing migraineurs from non-migraineurs (including HCs and patients with TTH) by the receiver operating characteristic (ROC) analysis. Associations between headache characteristics and rsFC features were calculated using a multi-linear regression model. This clinical trial protocol has been registered in the Chinese Clinical Trial Registry (registry number: ChiCTR1900024307, Registered: 5 July 2019-Retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=40817).
RESULTS
Migraineurs showed lower MoCA scores ( = 0.010) and higher SAS scores ( = 0.017) than HCs. Migraineurs also showed decreased rsFC in the bilateral calcarine/cuneus, lingual gyrus (seed: left amygdala), and bilateral calcarine/cuneus (seed: left hippocampus) in comparison to HCs and patients with TTH. These rsFC features demonstrated significant distinguishing capabilities and got a sensitivity of 82.6% and specificity of 81.8% with an area under the curve (AUC) of 0.868. rsFC alterations showed a significant correlation with headache frequency in migraineurs ( = 0.001, = 0.020).
CONCLUSION
The rsFC of amygdala and hippocampus with occipital lobe can be used to distinguish patients with migraine from patients with TTH.
CLINICAL TRIAL REGISTRATION
[http://www.chictr.org.cn/showproj.aspx?proj=40817], identifier [ChiCTR1900024307].
背景
偏头痛患者常表现出认知、情绪及静息态功能连接（rsFC）异常，而紧张型头痛（TTH）患者很少出现这些异常。本研究旨在探讨与认知和情绪相关脑区的rsFC改变是否可用于区分偏头痛患者和TTH患者。
方法
本研究采用蒙特利尔认知评估量表（MoCA）、焦虑自评量表（SAS）、抑郁自评量表（SDS）及rsFC分析，对24名健康对照者（HCs）、24名偏头痛患者和24名TTH患者的认知、焦虑和抑郁情况进行评估。由于双侧杏仁核和海马在神经心理功能中起重要作用，故选择其作为rsFC分析的种子区域。我们通过受试者工作特征（ROC）分析进一步评估rsFC潜在改变区分偏头痛患者与非偏头痛患者（包括HCs和TTH患者）的准确性。使用多线性回归模型计算头痛特征与rsFC特征之间的关联。本临床试验方案已在中国临床试验注册中心注册（注册号：ChiCTR1900024307，注册时间：2019年7月5日 - 回顾性注册，http://www.chictr.org.cn/showproj.aspx?proj=40817）。
结果
与HCs相比，偏头痛患者的MoCA评分更低（ = 0.010），SAS评分更高（ = 0.017）。与HCs和TTH患者相比，偏头痛患者双侧距状沟/楔叶、舌回（种子区域：左侧杏仁核）以及双侧距状沟/楔叶（种子区域：左侧海马）的rsFC也降低。这些rsFC特征显示出显著的区分能力，曲线下面积（AUC）为0.868，敏感性为82.6%，特异性为81.8%。rsFC改变与偏头痛患者的头痛频率显著相关（ = 0.001， = 0.020）。
结论
杏仁核和海马与枕叶的rsFC可用于区分偏头痛患者和TTH患者。
临床试验注册
[http://www.chictr.org.cn/showproj.aspx?proj=40817]，标识符[ChiCTR1900024307]
Zotero 插件