Wu Huimin, Song Yu, Chen Shanshan, Ge Honglin, Yan Zheng, Qi Wenzhang, Yuan Qianqian, Liang Xuhong, Lin Xingjian, Chen Jiu
Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Institute of Neuropsychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Front Neurosci. 2022 Apr 26;16:876568. doi: 10.3389/fnins.2022.876568. eCollection 2022.
Mild cognitive impairment (MCI) is known as the prodromal stage of the Alzheimer's disease (AD) spectrum. The recent studies have advised that functional alterations in the dorsal attention network (DAN) could be used as a sensitive marker to forecast the progression from MCI to AD. Therefore, our aim was to investigate specific functional alterations in the DAN in MCI.
We systematically searched PubMed, EMBASE, and Web of Science and chose relevant articles based on the three functional indicators, the amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and functional connectivity (FC) in the DAN in MCI. Based on the activation likelihood estimation, we accomplished the aggregation of specific coordinates and the analysis of functional alterations.
A total of 38 studies were involved in our meta-analysis. By summing up included articles, we acquired specific brain region alterations in the DAN mainly in the superior temporal gyrus (STG), middle temporal gyrus (MTG), superior frontal gyrus (SFG), middle frontal gyrus (MFG), inferior frontal gyrus (IFG), precentral gyrus (preCG), inferior parietal lobule (IPL), superior parietal lobule (SPL). At the same time, the key area that shows anti-interaction with default mode network included the IPL in the DAN. The one showing interactions with executive control network was mainly in the MFG. Finally, the frontoparietal network showed a close connection with DAN especially in the IPL and IFG.
This study demonstrated abnormal functional markers in the DAN and its interactions with other networks in MCI group, respectively. It provided the foundation for future targeted interventions in preventing the progression of AD.
[https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42021287958].
轻度认知障碍（MCI）被认为是阿尔茨海默病（AD）谱系的前驱阶段。最近的研究表明，背侧注意网络（DAN）的功能改变可作为预测MCI向AD进展的敏感标志物。因此，我们的目的是研究MCI患者DAN的特定功能改变。
我们系统检索了PubMed、EMBASE和Web of Science，并根据MCI患者DAN的三个功能指标，即低频振幅（ALFF）、局部一致性（ReHo）和功能连接（FC）选择相关文章。基于激活可能性估计，我们完成了特定坐标的汇总和功能改变分析。
我们的荟萃分析共纳入38项研究。通过总结纳入的文章，我们获得了DAN中特定脑区的改变，主要位于颞上回（STG）、颞中回（MTG）、额上回（SFG）、额中回（MFG）、额下回（IFG）、中央前回（preCG）、顶下小叶（IPL）、顶上小叶（SPL）。同时，与默认模式网络呈反相关的关键区域包括DAN中的IPL。与执行控制网络呈正相关的区域主要在MFG。最后，额顶网络与DAN显示出密切联系，尤其是在IPL和IFG。
本研究分别证明了MCI组DAN的功能标记异常及其与其他网络的相互作用。它为未来预防AD进展的靶向干预提供了基础。
