Baglin T P, Galvin G P, Pollock A
Cancer Genet Cytogenet. 1987 Jul;27(1):167-9. doi: 10.1016/0165-4608(87)90271-8.
Acute nonlymphocytic leukemia, apparently without a preleukemic phase, developed in a 48-year-old male who had received oral cyclophosphamide and razoxane in succession. Inversion of chromosome #16 was present in association with the morphologic features typically seen with this abnormality in de novo acute leukemia. Conventional chemotherapy resulted in complete remission, which lasted for 13 months. The importance of performing cytogenetic studies in cases of secondary leukemia is emphasized.
一名48岁男性在先后接受口服环磷酰胺和丙亚胺后，患急性非淋巴细胞白血病，且显然无前白血病期。#16号染色体倒位与原发性急性白血病中此异常典型所见的形态学特征相关。常规化疗导致完全缓解，持续了13个月。强调了在继发性白血病病例中进行细胞遗传学研究的重要性。
