Kantarjian H M, Keating M J, Walters R S, Beran M, McLaughlin P, McCredie K B, Freireich E J
Cancer. 1986 Aug 15;58(4):924-7. doi: 10.1002/1097-0142(19860815)58:4<924::aid-cncr2820580420>3.0.co;2-y.
Eight patients with secondary leukemia and specific cytogenetic abnormalities involving inversion of chromosome 16, or translocations between chromosomes 15 and 17, or 8 and 21, are presented. Seven of them (87%) achieved complete remission with chemotherapy. The occurrence of these karyotypes, which is unusual in secondary leukemia, and the favorable response to chemotherapy are discussed in relation to the pathogenesis of the disease.
本文报告了8例继发性白血病患者，这些患者具有特定的细胞遗传学异常，包括16号染色体倒位、15号与17号染色体易位或8号与21号染色体易位。其中7例（87%）通过化疗实现了完全缓解。本文结合该疾病的发病机制，讨论了这些在继发性白血病中不常见的核型的出现情况以及对化疗的良好反应。
