Jain R K
Cancer Res. 1987 Jun 15;47(12):3039-51.
The transport of fluid and solute molecules in the interstitium is governed by the biological and physicochemical properties of the interstitial compartment as well as the physicochemical properties of the test molecule. The composition of the interstitial compartment of neoplastic tissues is significantly different from that of most normal tissues. In general the tumor interstitial compartment is characterized by large interstitial space, high collagen concentration, low proteoglycan and hyaluronate concentrations, high interstitial fluid pressure and flow, absence of anatomically well-defined functioning lymphatic network, high effective interstitial diffusion coefficient of macromolecules, as well as large hydraulic conductivity and interstitial convection compared to most normal tissues. While these factors favor movement of macromolecules in the tumor interstitium, high interstitial pressure and low microvascular pressure may retard extravasation of molecules and cells, especially in large tumors. These differences in transport parameters have major implications in tumor growth and metastases, as well as in tumor detection and treatment.
间质中液体和溶质分子的运输受间质区室的生物学和物理化学性质以及测试分子的物理化学性质的支配。肿瘤组织间质区室的组成与大多数正常组织有显著差异。一般来说，肿瘤间质区室的特征是间质空间大、胶原蛋白浓度高、蛋白聚糖和透明质酸盐浓度低、间质液压力和流量高、缺乏解剖学上明确的功能性淋巴网络、大分子的有效间质扩散系数高，以及与大多数正常组织相比具有大的水力传导率和间质对流。虽然这些因素有利于大分子在肿瘤间质中的移动，但高间质压力和低微血管压力可能会阻碍分子和细胞的外渗，尤其是在大肿瘤中。这些运输参数的差异对肿瘤的生长和转移以及肿瘤的检测和治疗具有重要意义。
