Gelfand J A, Hurley D L, Fauci A S, Frank M M
J Infect Dis. 1978 Jul;138(1):9-16. doi: 10.1093/infdis/138.1.9.
The role of complement in experimental disseminated candidiasis was studied in normal guinea pigs, animals congenitally deficient in the fourth component of complement (C4), and animals depleted of alternative pathway activity by cobra venom factor (CVF). Animals pretreated with CVF and challenged with Candida albicans had a high rate of mortality. Results of quantitative organ cultures corroborated prior reports that the kidney was the major target organ of infection. Infection of the kidney was markedly enhanced by CVF-induced depletion of the alternative pathway but not by classical pathway deficiency (deficiency in C4). There were differences among organs (kidney, liver, and spleen) in their requirement for complement to mount an effective host defense response. Ultimately, the integrity of the alternative pathway and late components of complement appears necessary for the limitation of and survival from sepsis due to C. albicans in nonimmune animals.
在正常豚鼠、先天性缺乏补体第四成分（C4）的动物以及被眼镜蛇毒因子（CVF）耗尽替代途径活性的动物中，研究了补体在实验性播散性念珠菌病中的作用。用CVF预处理并接种白色念珠菌的动物死亡率很高。定量器官培养结果证实了先前的报道，即肾脏是主要的感染靶器官。CVF诱导的替代途径耗竭显著增强了肾脏感染，但经典途径缺陷（C4缺乏）则没有。在对补体的需求方面，各器官（肾脏、肝脏和脾脏）存在差异，以启动有效的宿主防御反应。最终，对于非免疫动物中由白色念珠菌引起的败血症，替代途径和补体晚期成分的完整性似乎是限制感染并存活下来所必需的。
