通过酸催化的/-混合5,6-二芳基二吡咯乙烯的氧化大环化反应进行克级卟吩的合成。
Gram-scale synthesis of porphycenes through acid-catalyzed oxidative macrocyclizations of /-mixed 5,6-diaryldipyrroethenes.
作者信息
Ono Toshikazu, Xu Ning, Koga Daiki, Ideo Toshihiro, Sugimoto Manabu, Hisaeda Yoshio
机构信息
Department of Chemistry and Biochemistry, Graduate School of Engineering, Center for Molecular Systems (CMS), Kyushu University Fukuoka 819-0395 Japan
PRESTO, Japan Science and Technology Agency (JST) 4-1-8 Honcho Kawaguchi Saitama 332-0012 Japan.
出版信息
RSC Adv. 2018 Nov 26;8(69):39269-39273. doi: 10.1039/c8ra09040h. eCollection 2018 Nov 23.
The gram-scale production of porphycene derivatives is reported. This has been achieved by acid-catalyzed ring closure of an /-mixture of 5,6-diaryldipyrroethenes, resulting in the formation of -tetraarylporphycenes in yields of up to 80%. /-isomerization of the 5,6-diaryldipyrroethenes under acidic conditions was key to proceed the effective macrocyclization.
报道了卟吩衍生物的克级规模制备。这是通过酸催化5,6-二芳基二吡咯乙烯的/-混合物闭环反应实现的，生成-四芳基卟吩的产率高达80%。5,6-二芳基二吡咯乙烯在酸性条件下的/-异构化是有效进行大环化反应的关键。
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