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一种适用于合成2-芳基苯并咪唑和2-芳基苯并噻唑的现代实用的漆酶催化路线。

A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles.

作者信息

Maphupha Mudzuli, Juma Wanyama P, de Koning Charles B, Brady Dean

机构信息

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand Johannesburg South Africa

出版信息

RSC Adv. 2018 Nov 27;8(69):39496-39510. doi: 10.1039/c8ra07377e. eCollection 2018 Nov 23.

DOI:10.1039/c8ra07377e
PMID:35558053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9090715/
Abstract

Heterocyclic aromatic compounds containing an imine (C[double bond, length as m-dash]N) bond such as benzimidazoles and benzothiazoles are important active pharmaceutical ingredients. The synthesis of 2-aryl-1-benzimidazoles and 2-arylbenzothiazoles in good to excellent yields was achieved by reacting 2-aminoaromatics with various benzaldehyde derivatives catalysed by the commercial laccases Novoprime and Suberase® at room temperature and in the presence of atmospheric oxygen.

摘要

含有亚胺（C=N）键的杂环芳香化合物，如苯并咪唑和苯并噻唑，是重要的活性药物成分。通过在室温及大气氧存在下，使2-氨基芳烃与各种苯甲醛衍生物在市售漆酶Novoprime和Suberase®催化下反应，以良好至优异的产率实现了2-芳基-1-苯并咪唑和2-芳基苯并噻唑的合成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/d8bdbd9a3f26/c8ra07377e-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/1e939dcf4b81/c8ra07377e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/8efb36a276ae/c8ra07377e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/5d46962f9519/c8ra07377e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/d456f68c557a/c8ra07377e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/7692fe7e110f/c8ra07377e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/04a81eac0ddf/c8ra07377e-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/cf8e8ae6f395/c8ra07377e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/bad44261fe38/c8ra07377e-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/d8bdbd9a3f26/c8ra07377e-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/1e939dcf4b81/c8ra07377e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/8efb36a276ae/c8ra07377e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/5d46962f9519/c8ra07377e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/d456f68c557a/c8ra07377e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/7692fe7e110f/c8ra07377e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/04a81eac0ddf/c8ra07377e-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/cf8e8ae6f395/c8ra07377e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/bad44261fe38/c8ra07377e-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9093/9090715/d8bdbd9a3f26/c8ra07377e-s4.jpg

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