来自中国苔类植物的蒈烷型和桉烷型倍半萜类化合物及其抗糖尿病肾病的潜力。
Cyperane and eudesmane-type sesquiterpenoids from Chinese liverwort and their anti-diabetic nephropathy potential.
作者信息
Zhang Jiaozhen, Wang Yongjie, Zhu Rongxiu, Li Yi, Li Yuelan, Qiao Yanan, Zhou Jinchuan, Lou Hongxiang
机构信息
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University Jinan 250012 People's Republic of China
Department of Pharmacy, The Second Hospital of Shandong University Jinan Shandong 250033 People's Republic of China.
出版信息
RSC Adv. 2018 Nov 22;8(68):39091-39097. doi: 10.1039/c8ra08125e. eCollection 2018 Nov 16.
Six new sesquiterpenoids, including cyperane (1 and 2) and eudesmane (3-6) types, and one known eudesmane derivative (7), were isolated from the Chinese liverwort var. rivularis (Schrad.) Nees. The structures of 1-7 were determined based on a combination of their spectroscopic data (NMR, HRESIMS and IR), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations. Preliminary anti-diabetic nephropathy activity testing showed that the cyperane-type sesquiterpenoids could inhibit cell proliferation and extracellular matrix accumulation in high glucose cultured mesangial cells in a dose-dependent manner.
从中国产的地钱属植物耳状地钱（Schrad.）Nees中分离出6个新的倍半萜类化合物，包括蒈烷型（1和2）和桉叶烷型（3 - 6），以及1个已知的桉叶烷衍生物（7）。通过综合光谱数据（核磁共振、高分辨电喷雾电离质谱和红外光谱）、单晶X射线衍射和电子圆二色光谱（ECD）计算确定了1 - 7的结构。初步的抗糖尿病肾病活性测试表明，蒈烷型倍半萜类化合物能够以剂量依赖的方式抑制高糖培养的系膜细胞的增殖和细胞外基质积累。
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