Zwillich C W, Natalino M R, Sutton F D, Weil J V
J Lab Clin Med. 1978 Aug;92(2):262-9.
Progesterone administration increase VE in man, but its effects on ventilatory response to hypercapnia and hypoxia have not been well documented. Accordingly, VE, HVR, and HCVR were measured during placebo and MPA administration in 11 normal men. The effect of MPA (20 mg orally q 8 hr for 32 hr) on T degrees, metabolic rate (VO2 and VCO2) was also determined. With MPA, T degrees, rose 0.4 degrees C +/- 0.0008 (S.E.M.) p less than 0.0001), VE increased 0.46 +/- 0.16 L/min (p less than 0.01), and VO2 and VCO2 did not change significantly. HCVR (measured under hyperoxic conditions during rebreathing) increased significantly (P less than 0.01) from 2.9 +/- 0.33 L/min/mm Hg (placebo) to 4.0 +/- 0.29 (MPA). HVR was measured as the shape parameter A, so that when A increased, HVR was augmented. During MPA, HVR increased from A = 132 +/- 19.1 to 179 +/- 20.5 (P less than 0.02). We conclude that 60 mg of MPA daily in normal men increases VE and chemosensitivity as measured by the ventilatory response to hypercapnia and hypoxia.
给予孕酮可增加男性的每分钟静息通气量（VE），但其对高碳酸血症和低氧通气反应的影响尚无充分文献记载。因此，我们对11名正常男性在服用安慰剂和甲羟孕酮（MPA）期间测量了VE、高碳酸血症通气反应（HCVR）和低氧通气反应（HVR）。还测定了MPA（口服20mg，每8小时一次，共32小时）对体温（T）、代谢率（VO2和VCO2）的影响。服用MPA后，体温升高0.4℃±0.0008（标准误）（P＜0.0001），VE增加0.46±0.16L/min（P＜0.01），VO2和VCO2无显著变化。HCVR（在重复呼吸的高氧条件下测量）从2.9±0.33L/min/mm Hg（安慰剂）显著增加（P＜0.01）至4.0±0.29（MPA）。HVR以形状参数A来测量，因此当A增加时，HVR增强。服用MPA期间，HVR从A = 132±19.1增加至179±20.5（P＜0.02）。我们得出结论，正常男性每日服用60mg MPA可增加VE以及通过对高碳酸血症和低氧的通气反应所测量的化学敏感性。
