非诺特罗对正常受试者低氧和高碳酸血症通气反应的影响。

Effects of fenoterol on ventilatory responses to hypoxia and hypercapnia in normal subjects.

作者信息

Yoshiike Y, Suzuki S, Watanuki Y, Okubo T

机构信息

First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.

出版信息

Thorax. 1995 Feb;50(2):139-42. doi: 10.1136/thx.50.2.139.

DOI:10.1136/thx.50.2.139

PMID:7701451

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC473901/

Abstract

BACKGROUND

The effects of beta 2 adrenergic agonists on chemoreceptors remain controversial. This study was designed to examine whether fenoterol, a beta 2 adrenergic agonist, increases the ventilatory responses to hypercapnia (HCVR) and hypoxia (HVR) in normal subjects.

METHODS

HCVR was tested with a rebreathing method and HVR was examined with a progressive isocapnic hypoxic method in 11 normal subjects. Both HCVR and HVR were assessed by the slope of occlusion pressure (P0.1) or ventilation (VE) plotted against end tidal carbon dioxide pressure and arterial oxygen saturation, respectively. Respiratory muscle strength, spirometric values and lung volume were measured. After a single oral administration of 5 mg fenoterol or placebo HCVR and HVR were evaluated.

RESULTS

Fenoterol treatment did not change the specific airway conductance or forced expiratory volume in one second. Respiratory muscle strength did not change. Fenoterol increased the slope of the HCVR of both P0.1 (from 0.251 (0.116) to 0.386 (0.206) kPa/kPa, average increase 71%) and VE (from 10.7 (3.4) to 15.1 (4.2) l/min/kPa, average increase 52%), and shifted the response curves to higher values. For the HVR fenoterol increased the slopes of both P0.1 and VE (from -4.06 (2.00) x 10(-3) to -7.99 (4.29) x 10(-3) kPa/%, an average increase of 83%, and from -0.221 (0.070) to -0.313 (0.112) l/min/%, a 44.5% increase, respectively), and shifted the response curves to higher values.

CONCLUSION

Acute administration of fenoterol increases the ventilatory responses to both hypercapnia and hypoxia in normal subjects.

摘要

背景

β2肾上腺素能激动剂对化学感受器的作用仍存在争议。本研究旨在探讨β2肾上腺素能激动剂非诺特罗是否会增加正常受试者对高碳酸血症（HCVR）和低氧血症（HVR）的通气反应。

方法

采用再呼吸法对11名正常受试者进行HCVR测试，采用渐进等碳酸血症低氧法进行HVR测试。分别通过绘制阻断压（P0.1）或通气量（VE）与呼气末二氧化碳分压和动脉血氧饱和度的斜率来评估HCVR和HVR。测量呼吸肌力量、肺量计值和肺容积。单次口服5mg非诺特罗或安慰剂后，评估HCVR和HVR。

结果

非诺特罗治疗未改变比气道传导率或一秒用力呼气量。呼吸肌力量未改变。非诺特罗增加了P0.1的HCVR斜率（从0.251（0.116）kPa/kPa增加到0.386（0.206）kPa/kPa，平均增加71%）和VE斜率（从10.7（3.4）l/min/kPa增加到15.1（4.2）l/min/kPa，平均增加52%），并将反应曲线移至更高值。对于HVR，非诺特罗增加了P0.1和VE的斜率（分别从-4.06（2.00）×10⁻³kPa/%增加到-7.99（4.29）×10⁻³kPa/%，平均增加83%，以及从-0.221（0.070）l/min/%增加到-0.313（0.112）l/min/%，增加44.5%），并将反应曲线移至更高值。