Levin H S, Peters B H, Kalisky Z, High W M, von Laufen A, Eisenberg H M, Morrison D P, Gary H E
Cent Nerv Syst Trauma. 1986 Fall;3(4):333-42. doi: 10.1089/cns.1986.3.333.
In view of the evidence for the role of the central cholinergic pathways in memory and preliminary studies suggesting alteration of neurotransmitters after severe head injury, we completed a double-blind, placebo-controlled study of combined oral physostigmine and lecithin. Sixteen survivors of moderate to severe closed head injury who had unequivocal memory deficit were studied during the course of inpatient rehabilitation. Although the results generally indicated no difference in the effects of the physostigmine-lecithin combination as compared to lecithin alone, sustained attention on the continuous performance test was more efficient under physostigmine than placebo when the drug condition occurred first in the crossover design. Further investigation of neurotransmitter manipulation is warranted in patients with traumatic brain injury.
鉴于中枢胆碱能通路在记忆中所起作用的证据，以及初步研究表明严重颅脑损伤后神经递质会发生改变，我们完成了一项关于口服毒扁豆碱与卵磷脂联合使用的双盲、安慰剂对照研究。在住院康复过程中，对16名中度至重度闭合性颅脑损伤且有明确记忆缺陷的幸存者进行了研究。虽然结果总体表明，与单独使用卵磷脂相比，毒扁豆碱 - 卵磷脂联合使用的效果没有差异，但在交叉设计中，当药物条件首先出现时，在持续操作测试中，毒扁豆碱作用下的持续注意力比安慰剂更有效。对于创伤性脑损伤患者，有必要进一步研究神经递质调控。
