Bai Zhongxiang, Dan Weihua, Yu Guofei, Wang Yanjun, Chen Yining, Huang Yanping, Yang Changkai, Dan Nianhua
Research Center of Biomedical Engineering (Sichuan University) Chengdu 610065 China
State Key Laboratory of Polymer Materials Engineering (Sichuan University), Polymer Research Institute of Sichuan University Chengdu 610065 China.
RSC Adv. 2018 Dec 18;8(73):42123-42132. doi: 10.1039/c8ra07697a. eCollection 2018 Dec 12.
Natural collagen has good biocompatibility and ability to promote tissue regeneration; however, its low flexibility and easy degradation hinder its applications in wound repair. In this study, we synthesized a skin wound-repairing hydrogel with good bioactivity and high toughness and adhesion. Inspired by the good adhesion of natural mussels, dopamine was grafted onto oxidized sodium alginate to synthesize a new crosslinker (COA), which was introduced into the collagen/polyacrylamide (PAM-Col) double network to synthesize hydrogel. The morphological characterization of the hydrogel using scanning electron microscopy confirmed that the hydrogel formed a more chaotic interconnected structure after the introduction of COA. PAM-Col-COA hydrogel had good mechanical properties, skin tissue adhesion, water absorption, and sustained biological activity. wound healing experiments showed that hydrogel accelerates the wound healing process and has potential applications in wound dressings.
天然胶原蛋白具有良好的生物相容性和促进组织再生的能力；然而，其低柔韧性和易降解性阻碍了其在伤口修复中的应用。在本研究中，我们合成了一种具有良好生物活性、高韧性和粘附性的皮肤伤口修复水凝胶。受天然贻贝良好粘附性的启发，将多巴胺接枝到氧化海藻酸钠上合成一种新型交联剂（COA），将其引入胶原蛋白/聚丙烯酰胺（PAM-Col）双网络中合成水凝胶。使用扫描电子显微镜对水凝胶进行形态表征证实，引入COA后水凝胶形成了更杂乱的相互连接结构。PAM-Col-COA水凝胶具有良好的力学性能、皮肤组织粘附性、吸水性和持续生物活性。伤口愈合实验表明，水凝胶加速了伤口愈合过程，在伤口敷料方面具有潜在应用。
