暴露于低强度磁场的磁脂质体水悬浮液的控释。
Controlled release from magnetoliposomes aqueous suspensions exposed to a low intensity magnetic field.
作者信息
Spera Romina, Petralito Stefania, Liberti Micaela, Merla Caterina, d'Inzeo Guglielmo, Pinto Rosanna, Apollonio Francesca
机构信息
Department of Chemistry and Drug Technology, Sapienza University of Rome, Rome, Italy.
出版信息
Bioelectromagnetics. 2014 May;35(4):309-12. doi: 10.1002/bem.21841. Epub 2014 Jan 31.
Recently, the use of liposomes loaded with magnetic nanoparticles (magnetoliposomes, (MLs)) has been intensely growing as a new drug delivery system. With the use of alternating magnetic fields, it is possible to remotely control the delivery of a drug or any other macromolecule loaded inside the MLs. In this experiment, the release of a fluorescent dye from MLs is achieved through an alternating magnetic field of 20 kHz and amplitude below 100 A/m, and without a macroscopic temperature increase.
最近，作为一种新型药物递送系统，负载磁性纳米颗粒的脂质体（磁脂质体，MLs）的应用一直在迅速增长。通过使用交变磁场，可以远程控制MLs内负载的药物或任何其他大分子的递送。在本实验中，通过20kHz、振幅低于100A/m的交变磁场实现了荧光染料从MLs中的释放，且没有宏观温度升高。
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