Nanotechnology Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
J Control Release. 2015 May 28;206:161-76. doi: 10.1016/j.jconrel.2015.03.020. Epub 2015 Mar 20.
Design and synthesis of efficient drug delivery systems are of vital importance for medicine and healthcare. Nanocarrier-based drug delivery systems, in particular nanoparticles, have generated great excitement in the field of drug delivery since they provide new opportunities to overcome the limitations of conventional delivery methods with regards to the drugs. Silk fibroin (SF) is a naturally occurring protein polymer with several unique properties that make it a suitable material for incorporation into a variety of drug delivery vehicles capable of delivering a range of therapeutic agents. SF matrices have been shown to successfully deliver anticancer drugs, small molecules, and biomolecules. This review will provide an in-depth discussion of the development of SF nanoparticle-based drug delivery systems.
设计和合成高效的药物传递系统对于医学和医疗保健至关重要。基于纳米载体的药物传递系统，特别是纳米颗粒，在药物传递领域引起了极大的关注，因为它们为克服传统传递方法的局限性提供了新的机会。丝素蛋白（SF）是一种天然存在的蛋白质聚合物，具有多种独特的性质，使其成为可将各种治疗剂递送至多种药物传递载体中的合适材料。SF 基质已被证明可成功传递抗癌药物、小分子和生物分子。本综述将深入讨论 SF 纳米颗粒药物传递系统的发展。
