Wang Yi, Cui Qiyao, Zhao Xiaoshuang, Qin Tang, Wang Wenjing, Sun Hongmei, Zhu Hongda, Guo Huiling, Sun Honghao
School of Bioengineering and Food, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology Wuhan 430068 China
RSC Adv. 2018 Dec 11;8(72):41454-41463. doi: 10.1039/c8ra06176a. eCollection 2018 Dec 7.
Synergistic photothermal therapy (PTT) and chemotherapy is an efficient strategy for tumor therapy. However, it is still a challenge to design a smart delivery system able to release a drug at the appropriate time and site of action. Here, we have synthesized photosensitive molecule 7-(double dodecylamine)-4-hydroxymethylcoumarin which was introduced in a nanocarrier GNR@SiO-DOX@CouC-HA (GSDCH) to achieve manually controlled drug release. The specific nanocarrier was fabricated using a GNR core for photothermal therapy, a mesoporous silica shell for drug loading, and the coumarin moiety as a blocking agent and intelligent controlled switch. In addition, cellular uptake of GSDCH by HeLa cells can be achieved effectively with the help of hyaluronic acid (HA). Owing to the controlled and targeted drug release properties, the GSDCH with photothermal- and chemo-therapy showed significantly enhanced therapeutic efficiency for HeLa tumor-bearing mice compared to the results of single therapy alone. It indicated that the GSDCH had great potential in tumor therapy with negligible systematic toxicity.
协同光热疗法（PTT）与化疗是一种有效的肿瘤治疗策略。然而，设计一种能够在适当的作用时间和部位释放药物的智能递送系统仍然是一项挑战。在此，我们合成了光敏分子7-（双十二烷基胺）-4-羟甲基香豆素，并将其引入纳米载体GNR@SiO-DOX@CouC-HA（GSDCH）中，以实现手动控制药物释放。特定的纳米载体是利用用于光热疗法的GNR核、用于药物负载的介孔二氧化硅壳以及香豆素部分作为阻断剂和智能控制开关制备而成。此外，借助透明质酸（HA）可有效实现HeLa细胞对GSDCH的摄取。由于具有可控和靶向药物释放特性，与单独的单一疗法相比，具有光热和化疗功能的GSDCH对荷HeLa瘤小鼠显示出显著增强的治疗效果。这表明GSDCH在肿瘤治疗中具有巨大潜力，且全身毒性可忽略不计。
