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Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization.精子磷脂酶Cζ的嵌合体揭示了受精时哺乳动物卵子细胞内钙离子振荡产生过程中不同蛋白质结构域的功能。
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Sperm-induced Ca2+ release during egg activation in mammals.哺乳动物卵激活过程中精子诱导的钙离子释放。
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The sperm phospholipase C-ζ and Ca2+ signalling at fertilization in mammals.哺乳动物受精过程中的精子磷脂酶C-ζ与Ca2+信号传导
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Regulation of diacylglycerol production and protein kinase C stimulation during sperm- and PLCzeta-mediated mouse egg activation.精子和磷脂酶Cζ介导的小鼠卵母细胞激活过程中二酰甘油生成的调控及蛋白激酶C的激活
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Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.不育男性精子中磷脂酶Cζ（PLCζ）含量降低及形态异常。
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Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activation.人 PLCζ 比小鼠 PLCζ 在触发哺乳动物卵母细胞激活所需的 Ca(2+) 振荡方面表现出更高的受精能力。
Mol Hum Reprod. 2014 Jun;20(6):489-98. doi: 10.1093/molehr/gau011. Epub 2014 Jan 29.

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Genomic Insights into Fertilization: Tracing PLCZ1 Orthologs Across Amphibian Lineages.受精的基因组学见解：追踪两栖动物谱系中的磷脂酶Cζ1直系同源基因。
Genome Biol Evol. 2025 Apr 3;17(4). doi: 10.1093/gbe/evaf052.
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The signal that stimulates mammalian embryo development.刺激哺乳动物胚胎发育的信号。
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Development of Recombinant PLC-Zeta Protein as a Therapeutic Intervention for the Clinical Treatment of Oocyte Activation Failure.重组磷脂酶C-ζ蛋白作为卵母细胞激活失败临床治疗的治疗性干预措施的研发
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Oocyte activation is a cytoplasm-confined event so far: what about the nucleus?卵母细胞激活是一个迄今为止局限于细胞质的事件：那么细胞核呢？
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Renaissance in sperm cytoplasmic contribution to infertility.精子细胞质对不育症影响的研究新进展
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Successful Production of Offspring Derived from Phospholipase C Zeta-Deficient Sperm by Additional Artificial Activation.通过额外的人工激活成功产生源自磷脂酶Cζ缺陷精子的后代。
Life (Basel). 2023 Apr 10;13(4):980. doi: 10.3390/life13040980.
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IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect.IQCN 缺失导致顶体组装缺陷，从而引发受精失败和男性不育。
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本文引用的文献

1
SPERM FACTORS AND EGG ACTIVATION: The structure and function relationship of sperm PLCZ1.精子因子与卵子激活：精子 PLCZ1 的结构与功能关系。
Reproduction. 2022 May 23;164(1):F1-F8. doi: 10.1530/REP-21-0477.
2
SPERM FACTORS AND EGG ACTIVATION: ICSI and the discovery of the sperm factor and PLCZ1.精子因素与卵子激活：ICSI 技术与精子因子和 PLCZ1 的发现。
Reproduction. 2022 May 23;164(1):F9-F20. doi: 10.1530/REP-21-0487.
3
SPERM FACTORS AND EGG ACTIVATION: Phospholipase C zeta (PLCZ1) and the clinical diagnosis of oocyte activation deficiency.精子因素与卵子激活：PLCZ1 与卵母细胞激活缺陷的临床诊断。
Reproduction. 2022 May 23;164(1):F53-F66. doi: 10.1530/REP-21-0458.
4
SPERM FACTORS AND EGG ACTIVATION: Divergent sperm factors for egg activation in amphibian fertilization.精子因子与卵子激活：两栖类受精中激活卵子的不同精子因子。
Reproduction. 2022 May 23;164(1):F29-F37. doi: 10.1530/REP-21-0480.
5
SPERM FACTORS AND EGG ACTIVATION: The phenotype of PLCZ1-deficient mice.精子因子和卵子激活：PLCZ1 缺陷型小鼠的表型。
Reproduction. 2022 May 23;164(1):F21-F28. doi: 10.1530/REP-21-0438.
6
SPERM FACTORS AND EGG ACTIVATION: Fertilization failure after human ICSI and the clinical potential of PLCZ1.精子因素与卵子激活：人卵胞浆内单精子注射受精失败及 PLCZ1 的临床潜能
Reproduction. 2022 May 23;164(1):F39-F51. doi: 10.1530/REP-21-0387.
7
Molecular triggers of egg activation at fertilization in mammals.哺乳动物受精时卵子激活的分子触发因素。
Reproduction. 2016 Aug;152(2):R41-50. doi: 10.1530/REP-16-0123. Epub 2016 May 10.
8
PLCζ and its role as a trigger of development in vertebrates.PLCζ 及其在脊椎动物发育中的触发作用。
Mol Reprod Dev. 2011 Oct-Nov;78(10-11):846-53. doi: 10.1002/mrd.21359. Epub 2011 Aug 5.
9
Release of phospholipase C zetaand [Ca2+]i oscillation-inducing activity during mammalian fertilization.哺乳动物受精过程中磷脂酶Cζ的释放及诱导[Ca2+]i振荡的活性
Reproduction. 2007 Nov;134(5):695-704. doi: 10.1530/REP-07-0259.
10
Functional, biochemical, and chromatographic characterization of the complete [Ca2+]i oscillation-inducing activity of porcine sperm.猪精子完整的[Ca2+]i振荡诱导活性的功能、生化及色谱表征
Dev Biol. 2005 Sep 15;285(2):376-92. doi: 10.1016/j.ydbio.2005.06.029.

SPERM FACTORS AND EGG ACTIVATION: PLCzeta as the sperm factor that activates eggs: 20 years on.

作者信息

Swann Karl

机构信息

1School of Biosciences, Cardiff University, The Sir Martin Evans Building, Cardiff, UK.

出版信息

Reproduction. 2022 Jun 3;164(1):E1-E4. doi: 10.1530/REP-22-0148.

DOI:10.1530/REP-22-0148
PMID:35559852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9175548/
Abstract
摘要